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Mixed cryoglobulinemia (MC) is common in patients with chronic hepatitis C virus (HCV) infection. Direct-acting antiviral (DAA) regimens are today very effective with sustained virological response rates (SVR12) above 90%. The objective of this study was to investigate the impact of DAA therapy on cryoglobulin clearance in patients with HCV-associated MC.
We focused on HCV patients with or without HIV with MC who had at least one cryoglobulin level assessment before and after DAA therapy and investigated the impact of DAA therapy on cryoglobulin clearance.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| HCV patients with mixed cryoglobulinemia | HCV patients with or without HIV presenting a mixed cryoglobulinemia and treated with direct-acting antiviral agents |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| DAA treatment | Drug | Patients were treated with direct-acting antiviral (DAA) treatment for 12 or 24 weeks |
|
| Measure | Description | Time Frame |
|---|---|---|
| Cryoglobulin level at the end of therapy | The primary outcome was the cryoglobulin level at the end of direct-acting antiviral treatment (week 12 or 24 according to treatment duration) | End of treatment (12 or 24 weeks) |
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Inclusion Criteria:
Exclusion Criteria:
-
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HCV patients with mixed cryoglobulinemia
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| Name | Affiliation | Role |
|---|---|---|
| Fabien Zoulim, MD, PhD | Hospices Civils de Lyon | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospices Civils de Lyon - Croix-Rousse Hospital | Lyon | 69004 | France |
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| ID | Term |
|---|---|
| D019698 | Hepatitis C, Chronic |
| C565141 | Cryoglobulinemia, Familial Mixed |
| ID | Term |
|---|---|
| D006526 | Hepatitis C |
| D000086982 | Blood-Borne Infections |
| D003141 | Communicable Diseases |
| D007239 | Infections |
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| ID | Term |
|---|---|
| D013812 | Therapeutics |
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| D006525 |
| Hepatitis, Viral, Human |
| D014777 | Virus Diseases |
| D018178 | Flaviviridae Infections |
| D012327 | RNA Virus Infections |
| D006521 | Hepatitis, Chronic |
| D006505 | Hepatitis |
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |