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An observational study to assess the effectiveness, health economic-relevant costs and participant reported outcomes in participants with Chronic lymphocytic leukemia (CLL) receiving venetoclax as a monotherapy or in combination with rituximab, obinutuzumab, ibrutinib, or acalabrutinib as prescribed at the discretion of the physician and in accordance with local clinical practice and label.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Participants Receiving Venetoclax | Participants with Chronic Lymphocytic Leukemia (CLL) receiving venetoclax. | ||
| Participants Receiving Venetoclax + Rituximab | Participants with CLL receiving venetoclax in combination with rituximab. | ||
| Participants Receiving Venetoclax + Obinutuzumab | Participants with CLL receiving venetoclax in combination with obinutuzumab. | ||
| Participants Receiving Venetoclax + Ibrutinib | Participants with CLL receiving venetoclax in combination with ibrutinib. | ||
| Participants Receiving Venetoclax + Acalabrutinib | Participants with CLL receiving venetoclax in combination with acalabrutinib. |
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| Measure | Description | Time Frame |
|---|---|---|
| Percentage of Participants Achieving Best Overall Response Rate (ORR) | ORR is defined as the percentage of participants achieving partial response (PR) and complete response with incomplete regeneration of bone marrow (CRi) and complete response (CR) according to physician's assessment to therapy with venetoclax. | Up to 12 months |
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Inclusion Criteria:
- Participant with chronic lymphocytic leukemia (CLL) who start venetoclax therapy can be included in the study if treated as specified in the local label for any specific line of treatment.
Exclusion Criteria:
- None
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Participants with chronic lymphocytic leukemia (CLL) administering venetoclax per the local label.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Johannes Huelsenbeck | Contact | +49 611-1720-3036 | johannes.huelsenbeck@abbvie.com | |
| Stefan Lorenz | Contact | stefan.lorenz@abbvie.com |
| Name | Affiliation | Role |
|---|---|---|
| ABBVIE INC. | AbbVie | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Universitaetsklinikum St. Poelten /ID# 221152 | Recruiting | Sankt Pölten | Lower Austria | 3100 | Austria | |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38421404 | Derived | Schwaner I, Kuhn T, Losem C, Wolff T, Otremba B, Zaiss M, Hulsenbeck J, Famulla K, Nosslinger T, Rossi D. Low incidence of tumor lysis syndrome in elderly patients with chronic lymphocytic leukemia treated with venetoclax under real-world conditions: results from the prospective observational VeRVe study. Ann Hematol. 2024 Jun;103(6):2013-2020. doi: 10.1007/s00277-024-05638-7. Epub 2024 Feb 29. |
| Label | URL |
|---|---|
| Related Info | View source |
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| Medizinische Universitaet Graz /ID# 221155 |
| Completed |
| Graz |
| Styria |
| 8010 |
| Austria |
| Landeskrankenhaus Salzburg-Universitaetsklinikum der PMU (LKH) /ID# 221153 | Active, not recruiting | Salzburg | 5020 | Austria |
| Hanusch Krankenhaus /ID# 221151 | Completed | Vienna | 1140 | Austria |
| Stauferklinikum Schwaebisch Gmuend /ID# 201518 | Completed | Mutlangen | Baden-Wurttemberg | 73557 | Germany |
| Onkologische Praxis /ID# 201545 | Completed | Stuttgart | Baden-Wurttemberg | 70174 | Germany |
| Schwarzwald-Baar-Klinikum /ID# 208176 | Active, not recruiting | Villingen-Schwenningen | Baden-Wurttemberg | 78052 | Germany |
| MVZ am Klinikum Aschaffenburg Onkologie /ID# 201548 | Active, not recruiting | Aschaffenburg | Bavaria | 63739 | Germany |
| Studienzentrum Aschaffenburg /ID# 204125 | Active, not recruiting | Aschaffenburg | Bavaria | 63739 | Germany |
| Gemeinschaftspraxis Dr. Heinrich und Prof. Bangerter /ID# 200950 | Completed | Augsburg | Bavaria | 86150 | Germany |
| Drs. Tanzer, Chirca, Stoeberl /ID# 202613 | Completed | Bad Reichenhall | Bavaria | 83435 | Germany |
| Internistische Schwerpunktpraxen, Erlangen /ID# 200949 | Completed | Erlangen | Bavaria | 91052 | Germany |
| Onkologie Hof /ID# 201531 | Completed | Hof | Bavaria | 95028 | Germany |
| Praxis Dr. Stauch /ID# 202611 | Active, not recruiting | Kronach | Bavaria | 96317 | Germany |
| VK&K Studien GbR /ID# 202614 | Active, not recruiting | Landshut | Bavaria | 84036 | Germany |
| Haemato-Onkologie /ID# 205236 | Active, not recruiting | Munich | Bavaria | 81241 | Germany |
| Praxis Dr. Kreher /ID# 202604 | Active, not recruiting | Bad Liebenwerda | Brandenburg | 04924 | Germany |
| Praxis Dres. Kiehl/Stein /ID# 210052 | Completed | Frankfurt (Oder) | Brandenburg | 15236 | Germany |
| MVZ f. Blut- u.Krebserkrankungen /ID# 206704 | Active, not recruiting | Potsdam | Brandenburg | 14467 | Germany |
| Ambulantes Tumorzentrum Bremerhaven /ID# 224353 | Completed | Bremerhaven | Free Hanseatic City of Bremen | 27576 | Germany |
| Centrum fuer Haematologie und Onkologie Bethanien /ID# 206701 | Active, not recruiting | Frankfurt am Main | Hesse | 60389 | Germany |
| MVZ Dres. Cordes & Partner /ID# 202598 | Active, not recruiting | Frankfurt am Main | Hesse | 60596 | Germany |
| Klinikum Frankfurt Hoechst /ID# 210048 | Completed | Frankfurt am Main | Hesse | 65929 | Germany |
| Praxis Dres. Tebbe/Mayer /ID# 206730 | Active, not recruiting | Kassel | Hesse | 34125 | Germany |
| Onkologische Kooperation Harz /ID# 201550 | Active, not recruiting | Goslar | Lower Saxony | 38642 | Germany |
| OAZ Hannover /ID# 201538 | Active, not recruiting | Hanover | Lower Saxony | 30171 | Germany |
| Onkolologische Praxis Oldenburg /ID# 202607 | Active, not recruiting | Oldenburg | Lower Saxony | 26121 | Germany |
| MVZ der Paracelsus-Klinik /ID# 201541 | Completed | Osnabrück | Lower Saxony | 49076 | Germany |
| Med. Studiengesellschaft Nord West GmbH /ID# 201535 | Completed | Westerstede | Lower Saxony | 26655 | Germany |
| Praxis Dres. Plewe/Losem /ID# 202606 | Active, not recruiting | Neuss | North Rhine-Westphalia | 41462 | Germany |
| Hämatologie und Onkologie /ID# 205247 | Active, not recruiting | Kaiserslautern | Rhineland-Palatinate | 67655 | Germany |
| Praxis Dr. Klaproth/Cura /ID# 216413 | Completed | Neunkirchen | Saarland | 66538 | Germany |
| Onkozentrum Dresden /ID# 202599 | Active, not recruiting | Dresden | Saxony | 01127 | Germany |
| BAG Freiberg-Richter, Jacobasch, Illmer, Wolf /ID# 201532 | Completed | Dresden | Saxony | 01307 | Germany |
| Luebecker Oncology Practice /ID# 200952 | Completed | Lübeck | Schleswig-Holstein | 23562 | Germany |
| Friedrich-Ebert-Krankenhaus GmbH /ID# 206206 | Active, not recruiting | Neumünster | Schleswig-Holstein | 24534 | Germany |
| Praxis Dres. Krober/Stosiek /ID# 206729 | Active, not recruiting | Regensburg | State of Berlin | 93053 | Germany |
| Caritas-Krankenhaus gGmbH /ID# 243212 | Completed | Bad Mergentheim | 97980 | Germany |
| MVZ Klinikum Mittelbaden GmbH /ID# 206207 | Completed | Baden-Baden | 76532 | Germany |
| Praxis für Hämatologie und Onkologie /ID# 241763 | Completed | Berlin | 10117 | Germany |
| Onkologische Schwerpunktpraxis /ID# 200953 | Completed | Berlin | 10707 | Germany |
| Praxis am Volkspark /ID# 243195 | Completed | Berlin | 10715 | Germany |
| Onkologie am Segelfliegerdamm /ID# 202603 | Completed | Berlin | 12487 | Germany |
| Pioh Dres. Draube & Partner /ID# 239507 | Completed | Cologne | 50674 | Germany |
| Praxis Dres. Prange-Krex/Mohm /ID# 210049 | Active, not recruiting | Dresden | 01307 | Germany |
| St. Georg Klinikum Eisenach gemeinnützige GmbH (GKE) /ID# 250200 | Completed | Eisenach | 99817 | Germany |
| Praxis fuer interdisziplinaere Onkolologie und Haematologie /ID# 206999 | Active, not recruiting | Freiburg im Breisgau | 79110 | Germany |
| MVZ Onkologie GmbH /ID# 212376 | Completed | Hagen | 58095 | Germany |
| onkomedic GbR /ID# 218354 | Completed | Halle | 06110 | Germany |
| OncoResearch Lerchenfeld GmbH /ID# 205237 | Active, not recruiting | Hamburg | 22081 | Germany |
| Onkologische Gemeinschaftspraxis /ID# 205239 | Active, not recruiting | Hamburg | 22767 | Germany |
| Evangelisches Krankenhaus Hamm /ID# 206703 | Active, not recruiting | Hamm | 59063 | Germany |
| Studienzentrum am Raschplatz /ID# 250180 | Completed | Hanover | 30161 | Germany |
| Studienbüro Kamal und Dorn GBR /ID# 234105 | Completed | Hanover | 30625 | Germany |
| Klinikum Idar-Oberstein GmbH /ID# 210046 | Active, not recruiting | Idar-Oberstein | 55743 | Germany |
| Praxis Fuchs/Koehler /ID# 243215 | Completed | Langenhessen | 63225 | Germany |
| Bruederkrankenhaus St. Josef Paderborn /ID# 202600 | Completed | Paderborn | 33098 | Germany |
| Onkologische Praxis GbR /ID# 206705 | Active, not recruiting | Porta Westfalica | 32457 | Germany |
| Praxis Dres. Decker/Lakner/Leithäuser /ID# 206208 | Active, not recruiting | Rostock | 18057 | Germany |
| Diakonieklinikum Schwaebisch Hall /ID# 206205 | Active, not recruiting | Schwäbisch Hall | 74523 | Germany |
| MVZ am Schlossgarten GmbH /ID# 210043 | Completed | Schwetzingen | 68723 | Germany |
| Kantonsspital Aarau AG /ID# 210034 | Completed | Aarau | Canton of Aargau | 5001 | Switzerland |
| Spital Thun /ID# 233714 | Completed | Thun | Canton of Bern | 3600 | Switzerland |
| Luzerner Kantonsspital /ID# 210029 | Completed | Lucerne | Canton of Lucerne | 6000 | Switzerland |
| Réseau Hospitalier Neuchâtelois /ID# 227865 | Recruiting | Neuchâtel | Canton of Neuchâtel | 2000 | Switzerland |
| Kantonsspital St. Gallen /ID# 223037 | Completed | Sankt Gallen | Canton of St. Gallen | 9007 | Switzerland |
| KSW Kantonsspital Winterthur /ID# 211068 | Completed | Winterthur | Canton of Zurich | 8400 | Switzerland |
| EOC Ospedale Regionale di Bellinzona e Valli /ID# 208782 | Completed | Bellinzona | Canton Ticino | 6500 | Switzerland |
| Kantonsspital Münsterlingen /ID# 210035 | Completed | Münsterlingen | Thurgau | 8596 | Switzerland |
| Inselspital, Universitaetsspital Bern /ID# 210031 | Completed | Bern | 3010 | Switzerland |
| ID | Term |
|---|---|
| D015451 | Leukemia, Lymphocytic, Chronic, B-Cell |
| D009369 | Neoplasms |
| D007938 | Leukemia |
| ID | Term |
|---|---|
| D015448 | Leukemia, B-Cell |
| D007945 | Leukemia, Lymphoid |
| D009370 | Neoplasms by Histologic Type |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D008232 | Lymphoproliferative Disorders |
| D008206 | Lymphatic Diseases |
| D007160 | Immunoproliferative Disorders |
| D007154 | Immune System Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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