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| Name | Class |
|---|---|
| National Institutes of Health (NIH) | NIH |
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Low back pain is a major cause of disability, especially in the working-age population. A total of 149 million working days are lost every year as a consequence of back pain. Intervertebral disc (IVD) degeneration is thought to play a major role in chronic back and neck pain. Decades of bench-top research in tissue mechanics have shown clear relationships between changes in mechanical properties and abnormal changes IVD structure and composition. Our overall hypothesis is that measurements of IVD mechanical properties can provide valuable information about its structure and composition for early diagnosis of degeneration, quantification of degeneration progress, and evaluation of treatment strategies. Magnetic Resonance Elastography (MRE) is an imaging method to quantify mechanical properties from soft tissues. The objectives of this study are to evaluating repeatability and collecting base line data from healthy individuals; and to apply MRE to patients with disc herniation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Healthy Individuals | Other | Healthy individuals will be imaged for comparison purposes |
|
| Disc Herniation | Other | Subjects diagnosed with Intervertebral Disc Herniation will be imaged to evaluate sensitivity of the proposed method. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Custom Magnetic Resonance Elastography Device | Other | Magnetic Resonance Elastography is an imaging method to measure mechanical properties of tissues. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Changes in mechanical properties of the herniated intervertebral disc | It is expected that MR Elastography can measure changes in mechanical properties of the herniated intervertebral disc. | 1 week |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Daniel H Cortes, PhD | Penn State University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Penn State University | State College | Pennsylvania | 16802 | United States |
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| ID | Term |
|---|---|
| D007405 | Intervertebral Disc Displacement |
| ID | Term |
|---|---|
| D013122 | Spinal Diseases |
| D001847 | Bone Diseases |
| D009140 | Musculoskeletal Diseases |
| D006547 | Hernia |
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| D020763 |
| Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |