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| ID | Type | Description | Link |
|---|---|---|---|
| 2017-A01822-51 | Other Identifier | ID-RCB number, ANSM |
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Systemic sclerosis is a rare pathology characterized by fibrosis and vascular lesion with skin, pulmonary, digestive and cardiac localisation. Calcinosis cutis is commonly described, but its prevalence and appear few documented in literature. Moreover, this studies used clinical observation to determine presence or absence of calcification, and rarely radiography, in particular for feet localisation. In the same way, skin calcification and organ injury association appear unclear. The aim of the study is firstly to determine prevalence of calcinosis cutis, with hand and feet radiography realisation in a cohort of systemic sclerosis patient. Secondly, will be determine the correlation between calcinosis and organ injury.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Systemic sclerosis patients |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Radiography | Radiation | Radiography of the hand and feet (face incident) the day of the inclusion |
|
| Measure | Description | Time Frame |
|---|---|---|
| Calcinosis cutis prevalence by radiographic assessment | at inclusion ( baseline) |
| Measure | Description | Time Frame |
|---|---|---|
| Demographic data | at inclusion ( baseline) | |
| Rodnan score | at inclusion ( baseline) | |
| Visceral localisation evaluation (cardiac, pulmonary, digestive) |
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Inclusion Criteria:
Exclusion Criteria:
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Systemic sclerosis patient in the national reference center for scleroderma (Lille, France)
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| Name | Affiliation | Role |
|---|---|---|
| Vincent SOBANSKI, MD | University Hospital, Lille | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hôpital Claude Huriez, CHU | Lille | France |
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| ID | Term |
|---|---|
| D012595 | Scleroderma, Systemic |
| D000092182 | Calcinosis Cutis |
| ID | Term |
|---|---|
| D003240 | Connective Tissue Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D012871 | Skin Diseases |
| D002114 | Calcinosis |
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| ID | Term |
|---|---|
| D014965 | X-Rays |
| ID | Term |
|---|---|
| D060733 | Electromagnetic Radiation |
| D055590 | Electromagnetic Phenomena |
| D060328 | Magnetic Phenomena |
| D055585 | Physical Phenomena |
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| Veinous punction | Procedure | Blood sample to analysis VEGF, endothelin 1, endostatin and P/GF, (ELISA method) |
|
| at inclusion ( baseline) |
| EUSTAR score | at inclusion ( baseline) |
| Medsger score | at inclusion ( baseline) |
| Quality of life evaluation (HAQ modified questionary) | at inclusion ( baseline) |
| Biologic vascular markers : VEGF, endothelin 1, endostatin and P/GF, (ELISA method) | at inclusion ( baseline) |
| D002128 | Calcium Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D011827 | Radiation |
| D011839 | Radiation, Ionizing |