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The purpose of the study was to verify the myocardial protective effect of RIPC in patients undergoing OPCABG.
66 patients scheduled for OPCABG are randomly assigned to a RIPC group(n=33) or a control group(n=33). In the RIPC group, 4 cycles of 5-min ischemia(using a blood pressure cuff inflated to 40mmHg over the patient's basic blood pressure) and 5-min repercussion are done on an upper limb before skin incision. Patients in the control group wear the same cuff on an upper limb but no pressure is applied. Anesthetic and surgical techniques are standardized during the trial. Serum inflammatory cytokines and cardiac injury markers will be measured before and after surgery. Internal mammary artery and saphenous vein tissues will be collected during the surgery to assess hypoxia-inducible factor (Hif)-1a and other signalling proteins.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| RIPC | Experimental | 4 cycles of 5-min ischemia(using a blood pressure cuff inflated to 40mmHg over the patient's basic blood pressure) and 5-min repercussion are done on an upper limb. |
|
| control | Sham Comparator | patient in control group using a blood pressure cuff on an upper limb without inflating |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| RIPC | Other | 4 cycles of 5-min ischemia(using a blood pressure cuff inflated to 40mmHg over the patient's basic blood pressure) and 5-min repercussion are done on an upper limb before skin incision. |
| Measure | Description | Time Frame |
|---|---|---|
| ICU staying time | the time patients spend in ICU after surgery | average of 1 year |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ke-fang Guo, Phd | Contact | 021-64041990 | guo.kefang@zs-hospital.sh.cn |
| Name | Affiliation | Role |
|---|---|---|
| Hui-lin Wang, Phd | Fudan University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Huilin Wang | Recruiting | Shanghai | Shanghai Municipality | 200233 | China |
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