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| ID | Type | Description | Link |
|---|---|---|---|
| 2017-A01845-48 | Registry Identifier | RCB |
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The purpose of this study is to describe respiratory disorders in patients with severe multiple sclerosis (EDSS from 6.5).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with severe MS | Other | polysomnography and functional pulmonary testings. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Polysomnography | Diagnostic Test | During polysomnographia and functional pulmonary testing, signs of diaphragmatic dysfunction responsible for respiratory disorders will be searched. |
| Measure | Description | Time Frame |
|---|---|---|
| Polysomnography | presence of phasic activation of respiratory muscles | Baseline only_during one night |
| Measure | Description | Time Frame |
|---|---|---|
| Respiratory function testing | difference between vital capacity upright and supine position (liter) | Baseline only |
| Respiratory function testing | maximal inspiratory pressure (mmHg) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Maillart Elisabeth, MD | Hopital de la Pitié Salpétrière | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Département de Neurologie-Groupe Hospitalier Pitié-Salpêtrière | Paris | Paris | 75013 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33538688 | Result | Zeidan S, Redolfi S, Papeix C, Bodini B, Louapre C, Arnulf I, Maillart E. Unexpected REM sleep excess associated with a pontine lesion in multiple sclerosis. J Clin Sleep Med. 2021 May 1;17(5):1117-1119. doi: 10.5664/jcsm.9114. |
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| ID | Term |
|---|---|
| D009103 | Multiple Sclerosis |
| D012120 | Respiration Disorders |
| ID | Term |
|---|---|
| D020278 | Demyelinating Autoimmune Diseases, CNS |
| D020274 | Autoimmune Diseases of the Nervous System |
| D009422 | Nervous System Diseases |
| D003711 | Demyelinating Diseases |
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| ID | Term |
|---|---|
| D017286 | Polysomnography |
| ID | Term |
|---|---|
| D008991 | Monitoring, Physiologic |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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|
| Baseline only |
| Respiratory function testing | maximal expiratory pressure (mmHg) | Baseline only |
| Respiratory function testing | SNIP (mmHg) | Baseline only |
| Respiratory function testing | peak flow (liter) | Baseline only |
| Cerebral and cervical spine MRI | cerebral : 3DT1MPRAGE, T2 FLAIR, DWI / spine: 3DT1MPRAGE, axial T2 MEDIC, T2-WSPACE | Baseline only |
| Expanded Disability Status Scale (EDSS) | Neurological assessment of disability related to multiple sclerosis, total score from 0 to 10 | Baseline only |
| BICAMS | Brief International Assessment for Multiple Sclerosis | Baseline only |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |
| D012140 | Respiratory Tract Diseases |