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Prospective randomized clinical trial Compare the goal-directed fluid therapy using esophageal Doppler and classic fluid therapy
Goal directed fluid therapy becomes issue for enhanced recovery after surgery. In goal directed therapy, dynamic parameters, like stroke volume and cardiac output, is important. Esophageal Doppler is one of device which provides dymanic parameters.
In severe trauma cases, the effect of goal directed therapy is not known yet. So the aim of this study is comparing the results of goal directed therapy using esophageal Doppler and conventional fluid therapy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| control | Monitoring arterial pressure, central venous pressure and pulse pressure variation | ||
| esophagela Doppler | Monitoring arterial pressure, central venous pressure Insertion of esophageal Doppler probe to patient Monitoring stroke volume, cardiac output, corrected flow time from esophageal Doppler Use stroke volume optimization goal directed therapy protocol |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| esophageal Doppler | Device | Goal directed fluid therapy using dynamic parameters from esophageal Doppler |
|
| Measure | Description | Time Frame |
|---|---|---|
| Lactate | Unit is mmol/L Inclusion criteria is initial lactate > 2mmol/L. Whole hospital use same device and unit to measure lactate. In this study, POCT lactate won't be used. After surgical resuscitation, lactate level is independent predictor of survival, because it represents tissue oxygenation. | Immediate postoperative (=initial ICU admission) |
| Measure | Description | Time Frame |
|---|---|---|
| Acute Physiology and Chronic Health Evaluation II (APACHE II) score | ICU patient scoring system, score from 0 to 71, higher scores correspond to more severe disease and a higher risk of death | Immediate postoperative |
| Creatinine |
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Inclusion Criteria:
Exclusion Criteria:
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Severe trauma patients
: Injury severity score > 15
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| Name | Affiliation | Role |
|---|---|---|
| In Kyong Yi, MD | Ajou University School of Medicine | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ajou university school of medicine | Suwon | Gyeonggi-do | 16499 | South Korea |
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| ID | Term |
|---|---|
| D014947 | Wounds and Injuries |
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Kidney function
| Immediate postop |