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Unable to begin study due to funding. PI has left organization.
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Platelet function will be tested in individuals on antiplatelet medications to determine the optimal storage methodology.
Subjects will undergo administration of antiplatelet drugs and then will receive platelets stored in a variety of methods. Platelet function will be measured serially.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control (Placebo) | Placebo Comparator | Subjects will receive infusion of placebo (saline). |
|
| Platelet storage routine | Active Comparator | Subjects will receive infusion of platelets stored by routine method. |
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| Platelet storage experimental | Experimental | Subjects will receive infusion of platelets stored by a novel methodology. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Infusion of Platelets | Biological | Platelets will be stored using novel, FDA approved, technique. Subjects will receive infusion of platelets stored by novel technique, routine storage, and placebo (saline). |
| Measure | Description | Time Frame |
|---|---|---|
| Change in platelet function | Frozen platelets will result in improvement in platelet function after transfusion. | 1 hour post-transfusion |
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Inclusion Criteria:
Exclusion Criteria:
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| ID | Term |
|---|---|
| D012965 | Sodium Chloride |
| ID | Term |
|---|---|
| D002712 | Chlorides |
| D006851 | Hydrochloric Acid |
| D017606 | Chlorine Compounds |
| D007287 | Inorganic Chemicals |
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crossover study of various storage infusions techniques with each subject receiving various fluids aliquots.
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the assesor of platelet function and the PI will be blinded to group.
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| Infusion of Platelets | Biological | Platelets will be stored using the routine platelet storage method. Subjects will receive infusion of platelets stored by routine storage method. |
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| Placebo | Biological | Subjects will receive infusion placebo (saline). |
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| D017670 |
| Sodium Compounds |