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| Name | Class |
|---|---|
| PZ Heilig Hart | UNKNOWN |
| PZ Sint-Camillus | UNKNOWN |
| University of Amsterdam | OTHER |
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The investigators evaluate the efficacy of a computerised program (T.O.P. tool) consisting of an approach avoidance training (AAT) (to retrain action tendencies for alcohol-related stimuli), a visual probe training (VPT) (to retrain attentional bias for alcohol-related stimuli) and the combination of both training procedures versus placebo training, as an add-on to treatment as usual (psycho-education and cognitive behavioral therapy).
The investigators include hospitalized detoxified alcohol-dependent patients, who receive a four week training procedure, existing of a pre-assessment, 6 training sessions and a post-assessment.
Outcome measures consist of behavioral measures (consumption of alcohol - self report over 1 year), questionnaires (AUDIT; craving on 9-point likert scale) and approach avoidance and visual probe measurement tasks.
A six month and 1 year follow-up is included (behavioral measures and AUDIT). Further, the investigators will also assess credibility (9-point likert scale) of the training procedure before the start of the training and immediately after the assessment of the AAT and VPT training.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| AAT active - VPT sham | Experimental | Approach avoidance training active intervention and visual probe training sham intervention |
|
| VPT active - AAT sham | Experimental | Visual probe training active condition and approach avoidance training sham condition |
|
| AAT active - VPT active | Experimental | Approach avoidance training active condition and visual probe training active condition |
|
| AAT sham - VPT sham | Sham Comparator | Approach avoidance training sham condition and visual probe training sham condition |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| active approach avoidance training and sham visual probe training | Behavioral | patients receive active AAT training and sham VPT training |
|
| Measure | Description | Time Frame |
|---|---|---|
| change in drink behavior | AUDIT score | baseline, at 6 months and 1-year post training: change in auditscores between baseline, 6 months and 1-year post-training, and differences between groups |
| Measure | Description | Time Frame |
|---|---|---|
| change in Retraining attentional bias | The effect on a VPT task | baseline and between 1 and 7 days after completion of the 6 training sessions: change |
| change in Retraining action tendencies | The effect on a AAT task |
| Measure | Description | Time Frame |
|---|---|---|
| change in drinking behavior | score of AUDIT-c (first 3 questions of the AUDIT) | baseline; At 3 months post-training: change in audit-c score at baseline and 3 months post training |
| Time to first drink |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| sarah C herremans, PhD, MD | UZ Gent | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Ghent | Ghent | 9000 | Belgium |
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| sham approach avoidance training and active visual probe training | Behavioral | patients receive sham AAT training and active VPT training |
|
| active approach avoidance training and active visual probe training | Behavioral | patients receive active AAT training and active VPT training |
|
| sham approach avoidance training and sham visual probe training | Behavioral | patients receive sham AAT training and sham VPT training |
|
| baseline and between 1 and 7 days after completion of the 6 training sessions: change in action tendencies |
Time it takes between finalization of the training and the day the patients drinks an alcoholic beverage
| assessed at 3 months post-training |
| Time to first drink | Time it takes between finalization of the training and the day the patients drinks an alcoholic beverage | assessed at 6 months post-training |
| Time to first drink | Time it takes between finalization of the training and the day the patients drinks an alcoholic beverage | assessed at 1 year post-training |
| Time to first heavy drinking day | Time it takes between finalization of the training and the day a female patient drinks ≥ 4 alcoholic units/day and a male patient drinks ≥ 5 alcoholic units/day | assessed at 3 months post-training |
| Time to first heavy drinking day | Time it takes between finalization of the training and the day a female patient drinks ≥ 4 alcoholic units/day and a male patient drinks ≥ 5 alcoholic units/day | assessed at 6 monthspost-training |
| Time to first heavy drinking day | Time it takes between finalization of the training and the day a female patient drinks ≥ 4 alcoholic units/day and a male patient drinks ≥ 5 alcoholic units/day | assessed at 1 year post-training |
| ID | Term |
|---|---|
| D000437 | Alcoholism |
| D012008 | Recurrence |
| ID | Term |
|---|---|
| D019973 | Alcohol-Related Disorders |
| D019966 | Substance-Related Disorders |
| D064419 | Chemically-Induced Disorders |
| D001523 | Mental Disorders |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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