Pharmacodynamics and Pharmacokinetics of Dexmedetomidine in Pediatric

The Safety、Efficacy and Pharmacokinetics of Dexmedetomidine Administered Through Different Routes in Pediatric

1. Acute Hemodynamic and respiratory Changes After Rapid Intravenous different doses of Dexmedetomidine in Pediatric.
2. Pharmacokinetics after a single Rapid Intravenous dose of Dexmedetomidine in Pediatric.
3. Pharmacokinetics after a single dose of Dexmedetomidine administered as a nasal spray in Pediatric.

Inclusion Criteria:

• selective operation of inguinal hernia repair、orthopedics operation or general surgery operation in children
• aged 3-9 years
• ASA I - II
• enter the operating room by himself without parents
• normal liver and kidney function
• no history of anesthesia medication allergy.

Exclusion Criteria:

• allergic to dexmedetomidine, similar active ingredients or excipients
• G-6-PD deficiency
• a history of arrhythmia, bronchial and cardiovascular diseases, abnormal liver function and so on
• a history of use of alpha 2 receptor agonists or antagonists.