Multiple Ascending Dose Study of HM12460A in Type 2 Diabetes Mellitus

A Phase 1, Multiple Ascending Dose, Glucose Clamp Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of HM12460A Compared to Insulin Glargine in Subjects With Type 2 Diabetes Mellitus

This is a phase 1 multiple ascending dose (MAD) study, conducted in subjects with Type 2 Diabetes Mellitus.

Inclusion Criteria:

• Type 2 diabetes mellitus
• Female subjects must be non-pregnant and non-lactating

Exclusion Criteria:

• Recurrent severe hypoglycemia or hypoglycemic unawareness or recent severe ketoacidosis, as judged by the Investigator
• Pregnant or lactating women
• Participation in an investigational study within 30 days prior to dosing