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| Name | Class |
|---|---|
| Seoul National University Bundang Hospital | OTHER |
| SMG-SNU Boramae Medical Center | OTHER |
| Ewha Womans University Mokdong Hospital | OTHER |
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Although monitoring fluid balance for continuous renal replacement therapy-treated patients is an important issue, most physicians usually use conventional methods such as the difference between the amount of intake and output (I & O), which is not objective way. Meanwhile, bioimpedance electrical vector analysis presents the patients' fluid status with more objective data. Thus, the investigators will investigate the clinical benefit for monitoring fluid balance when the investigators use InBody S10, one of representative bioimpedance electrical vector analysis, compared with conventional methods among the patients who need continuous renal replacement therapy.
Although monitoring fluid balance for continuous renal replacement therapy-treated patients is an important issue, most physicians usually use conventional methods such as the difference between the amount of intake and output (I & O), which is not objective way.
Meanwhile, bioimpedance electrical vector analysis presents the patients' fluid status with more objective data.
Thus, the investigators will investigate the clinical benefit for monitoring fluid balance by using InBody S10 (0, 1, 2-day, and 7-day from CRRT initiation), one of representative bioimpedance electrical vector analysis, compared with conventional methods among the patients who need continuous renal replacement therapy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| IO group | Active Comparator | Fluid overload will be removed in the patients who received continuous renal replacement therapy, but the amount of fluid removal are guided by the intake-output balance. |
|
| InBody group | Experimental | Fluid overload will be removed in the patients who received continuous renal replacement therapy, but the amount of fluid removal are guided by the bioimpedance analysis (InBody S10). |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| InBody group | Device | As one of representative BIVA, it provides the patients' fluid status with more objective data such as TBW, ECW, ICW, etc. |
|
| Measure | Description | Time Frame |
|---|---|---|
| The rate reaching euvolemia | To compare how many rates the two groups reach the euvolemia at 7 days from CRRT initiation | 7 days from CRRT initiation |
| Measure | Description | Time Frame |
|---|---|---|
| Clinical outcomes (28-, 60-, 90-day mortality) | To compare the mortality rates between the two groups | 28-, 60-, or 90-days |
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Inclusion Criteria:
Patients will be eligible for INCLUSION in the study if ALL the following criteria are met;
The treating clinician believes that the patient requires continuous renal replacement therapy for acute renal failure.
The treating clinicians anticipate treating the patient with continuous renal replacement therapy for at least 72 hours.
Informed consent has been obtained.
The patient fulfills ONE of the following clinical criteria for initiating continuous renal replacement therapy:
urine output < 100 ml/6 hr that has been unresponsive to fluid resuscitation measures
Patients who are over 5% of fluid overload or their total body water/height^2 ≥13 L/m^2
Exclusion Criteria:
Patients will be EXCLUDED from the study if, in the opinion or knowledge of the responsible clinician ANY of the following criteria are present:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Sejoong Kim, MD,PhD | Contact | +82-10-9496-4899 | sejoong@snubh.org | |
| Hyungjung Oh, MD,PhD | Contact | +82-2-2650-2907 | ohjmd@naver.com |
| Name | Affiliation | Role |
|---|---|---|
| Sejoong Kim, MD,PhD | Department of Internal Medicine, Bundang Seoul National University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Bundang Seoul National University Hospital | Recruiting | Seongnam-si | Gyeonggi-do | 13620 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30541593 | Derived | Oh HJ, An JN, Oh S, Rhee H, Lee JP, Kim DK, Ryu DR, Kim S. VolumE maNagement Under body composition monitoring in critically ill patientS on CRRT: study protocol for a randomized controlled trial (VENUS trial). Trials. 2018 Dec 12;19(1):681. doi: 10.1186/s13063-018-3056-y. |
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| ID | Term |
|---|---|
| D004487 | Edema |
| ID | Term |
|---|---|
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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One is control for the patients under conventional methods (I/O based fluid monitoring). The other is case for the patients under Inbody S10 methods.
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| IO group | Other | Fluid removal are guided by intake-output balance. |
|