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| Name | Class |
|---|---|
| Ministry of Health-Basra Health Directorate-Al-Sader Teaching Hospital | UNKNOWN |
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an interventional study to measure the possible effects of spironolactone ( an aldosterone antagonist) on the incidence of acute kidney injury after coronary angiography
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| placebo | Placebo Comparator |
| |
| Spironolactone | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Spironolactone | Drug | each patient will receive 200 mg of spironolactone as per his/her angiography premedications |
|
| Measure | Description | Time Frame |
|---|---|---|
| Acute kidney injury by K-DIGO guidelines | an absolute elevation of serum creatinine of 0.5mg/dl or 25% above baseline | 48-72 hrs |
| Measure | Description | Time Frame |
|---|---|---|
| acute kidney injury by NGAL | assessment of serum NGAL at admission and after 6 hrs to detect possible AKI in selected patients | 6 hours |
| Measure | Description | Time Frame |
|---|---|---|
| safety outcome: serum potassium | serum potassium after 6 hrs of angio | 6 hrs |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Alhasan Mujtaba, BCPS | Baghdad University/College of Pharmacy/Department of Clinical Pharmacy | Principal Investigator |
| Mohammed A Taher, Ph.D. | Baghdad University/College of Pharmacy/Department of Biochemistry | Study Chair |
| Mazin A Hazzaa', Ph.D. | Al-Sader teaching Hospital/Basra Cardiac Center/M.D. Cardiologist | Study Director |
| Hassan M Al Rubaye, Ph.D | Al-Sader teaching Hospital/Basra Cardiac Center/M.D. Cardiologist | Study Director |
| Assad H Kata, Ph.D | Al-Sader teaching Hospital/Basra Cardiac Center/M.D. Cardiologist | Study Director |
| Hayder K Abdullkreem, M.Sc | Head of the clinical laboratory department/ Al-Sader teaching hopital | Study Director |
| Hamid A Abdulsada, Ph.D | Al-Sader teaching Hospital/Basra Cardiac Center/M.D. Cardiologist | Study Director |
| Abdul Ameer A Abdul Hameed, PH.D | Al-Sader teaching Hospital/Basra Cardiac Center/M.D. Cardiologist | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Al-Sader Teaching Hospital | Basra | 00964 | Iraq |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29785539 | Derived | Mujtaba A, Taher MA, Hazza MA, Al-Rubaye HM, Kata AH, AbdulWahab H, AbdulBari A, AlRubay HK. The Effect of Spironolactone on the Incidence of Contrast-Induced Nephropathy in Patients Undergoing Cardiac Catheterization: Study Design and Rationale. Cardiol Ther. 2018 Jun;7(1):101-106. doi: 10.1007/s40119-018-0112-3. Epub 2018 May 21. |
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| ID | Term |
|---|---|
| D058186 | Acute Kidney Injury |
| ID | Term |
|---|---|
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
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| ID | Term |
|---|---|
| D013148 | Spironolactone |
| D035061 | Control Groups |
| ID | Term |
|---|---|
| D007783 | Lactones |
| D009930 | Organic Chemicals |
| D011283 | Pregnenes |
| D011278 | Pregnanes |
| D013256 |
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| Placebo Oral Tablet | Drug | Each patient will receive a placebo tablet as per his/her angiography premedications |
|
|
| D005261 |
| Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D015340 | Epidemiologic Research Design |
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D012107 | Research Design |
| D008722 | Methods |