Drug-drug Interaction Between Simvastatin and SHR3824

Drug Interaction Study of Henagliflozin and Simvastatin in Healthy Volunteers

the purpose of thr study is to investigate the potential interation between multiple oral doses of SHR3824 and single oral dose of Simvastatin in healthy adult volunteers.

Inclusion Criteria:

• Healthy male volunteers with a body mass index (BMI, a measure of a person's weight in relation to height) between 19 and 26 kg/m2

Exclusion Criteria:

• History of hypoglycemia
• History of urinary tract infections,or genital infections
• History of current clinically significant medical illness as determined by the Investigator
• Known allergy to SHR3824 or Simvastatin or any of the excipients of the formulation of SHR3824 or Simvastatin