The Association Between the Gut Microbiota Composition and Development of Delirium in ICU Patients
The Association Between the Gut Microbiota Composition and Development of Delirium in ICU Patients
To investigate whether the composition of the gut microbiota is different in patients that develop delirium during critical illness as compared to patients who do not.
We plan to include an equal number of patients admitted to the ICU, that either do or don't develop delirium during their course of critical illness. Samples of feces/rectal swaps will be taken at admission and again either when the patients become CAM-ICU positive, alternatively after 5 days admssion/at discharge in patients that remain CAM-ICU negative.
Samples are then sent to analyses for purification of bacterial DNA and metagenomic analysis.
Inclusion Criteria: Admission to the ICU, Disability to make informed consent due to critical illness -
Exclusion Criteria: Dementia. Delirium diagnosed prior to the ICU admission on the non-ICU floors. Coma. Indication for deep sedation (-4/-5).
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