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The purpose of this study is to elucidate the effect of dexmedetomidine on renal function and delayed graft function after kidney transplantation
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Dexmedetomidine (Group D) | Experimental | Dexmedetomidine infusion during surgery Dexmedetomidine was infused at a rate of 0.4 μg/kg/h starting immediately after anesthetic induction and continued until skin closure |
|
| Control (Group C) | Placebo Comparator | 0.9% NaCl infusion during surgery 0.9% NaCl was infused at a rate of 0.4 μg/kg/h starting immediately after anesthetic induction and continued until skin closure |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dexmedetomidine | Drug | dexmedetomidine was infused at a rate of 0.4 μg/kg/h starting immediately after anesthetic induction and continued until skin closure. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Serum creatinine level | postoperative 7 day |
| Measure | Description | Time Frame |
|---|---|---|
| incidence of delayed graft function | 7 days after surgery | |
| level of serum creatinine | maximum 30 days before surgery, 1 hour after surgery, 1 day, 2 day, 3 day, 5 day, 7 day after surgery | |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jin Ha Park, MD | Contact | 82-2-2228-2420 | 82-2-2227-7897 | realsummer@yuhs.ac |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine | Recruiting | Seoul | 03722 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34931289 | Derived | Park JH, Koo BN, Kim MS, Shin D, Kwak YL. Effects of intraoperative dexmedetomidine infusion on renal function in elective living donor kidney transplantation: a randomized controlled trial. Can J Anaesth. 2022 Apr;69(4):448-459. doi: 10.1007/s12630-021-02173-1. Epub 2021 Dec 20. |
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| ID | Term |
|---|---|
| D020927 | Dexmedetomidine |
| ID | Term |
|---|---|
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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participants, investicator, outcome assessors will be blinded for group allocation.
| placebo | Drug | 0.9% NaCl was infused at a rate of 0.4 μg/kg/h starting immediately after anesthetic induction and continued until skin closure |
|
| blood urea nitrogen (BUN) |
| maximum 30 days before surgery, 1 hour after surgery, 1 day, 2 day, 3 day, 5 day, 7 day after surgery |
| cystatin C | maximum 30 days before surgery, 1 hour after surgery, 1 day, 2 day, 3 day, 5 day, 7 day after surgery |
| Neutrophil gelatinase-associated lipocalin (NGAL) | maximum 30 days before surgery, 1 hour after surgery, 1 day, 2 day, 3 day, 5 day, 7 day after surgery |
| urine output | during surgery, 1 day, 2 day, 3 day, 4 day, 5 day, 6 day, 7 day after surgery |
| fluid intake(intraoperative intake and output measured by the amount of fluid(crystalloid/colloid)(mL) and blood administered(mL)) | during surgery, 1 day, 2 day, 3 day, 4 day, 5 day, 6 day, 7 day after surgery |
| kidney ultrasound | 1 week, 1 month after surgery, if possible |
| inflammatory mediator (IL-18, Il-1b) level | immediately after induction, immediately after vessel clamp, immediately after reperfusion, 1hour after surgery |