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To identify and describe long-term quality of life (QOL) issues in patients with metastatic melanoma treated with checkpoint inhibitors who achieved cancer control for a minimum of 12 months and remain on maintenance checkpoint inhibitor therapy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| online or telephone survey | This is a cross-sectional survey. Our main method of communication with patients will be email. Participants will complete a single online or telephone survey at a minimum of 12 months post initial treatment of checkpoint inhibitors and remain on maintenance therapy. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| EuroQoL EQ-5D-3L | Behavioral | Overall QOL |
| |
| Measure | Description | Time Frame |
|---|---|---|
| total score of Global QOL overall health index | On the EQ-5D-3L, respondents are asked to indicate their health state by marking the box associated with the most appropriate statement in each of the 5 dimensions, resulting in a one digit number expressing the level (1-3) selected for that dimension from no problems to extreme problems. | 1 year |
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Inclusion Criteria:
Exclusion Criteria:
Patients with cognitive, visual, or motor impairment such that they cannot complete the survey as assessed by the research or clinical team
Patients who developed a subsequent cancer after starting on checkpoint inhibitor(s), exclusive of non-melanoma superficial skin cancers
Patients with clinical documentation of progressive disease on the most recent assessment in the electronic medical record
Patients with symptomatic progression but continue on immunotherapy
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The melanoma service has agreed to provide this research team with access to a list of patients who are potentially eligible for this survey.
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| Name | Affiliation | Role |
|---|---|---|
| Deborah Korenstein, MD | Memorial Sloan Kettering Cancer Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Memoral Sloan Kettering Basking Ridge | Basking Ridge | New Jersey | 07920 | United States | ||
| Memoral Sloan Kettering Monmouth |
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| Label | URL |
|---|---|
| Memorial Sloan Kettering Cancer Center | View source |
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| EORTC QLQ-C30 |
| Behavioral |
General symptoms; physical, role, emotional, cognitive, and social functioning scales; fatigue, nausea/vomiting , and pain scales |
|
| PRO-CTCAE | Other | Additional potential immune-specific symptoms |
|
| Fatigue severity score questionnaire | Behavioral | Fatigue severity |
|
| The COST | Behavioral | Financial toxicity; satisfaction with ability to work |
|
| Physician information | Behavioral | Details on outside health providers |
|
| Middletown |
| New Jersey |
| 07748 |
| United States |
| Memorial Sloan Kettering Commack | Commack | New York | 11725 | United States |
| Memorial Sloan Kettering Westchester | Harrison | New York | 10604 | United States |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | United States |
| Memorial Sloan Kettering Rockville Centre | Rockville Centre | New York | 11570 | United States |
| ID | Term |
|---|---|
| D008545 | Melanoma |
| ID | Term |
|---|---|
| D018358 | Neuroendocrine Tumors |
| D017599 | Neuroectodermal Tumors |
| D009373 | Neoplasms, Germ Cell and Embryonal |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D009380 | Neoplasms, Nerve Tissue |
| D018326 | Nevi and Melanomas |
| D012878 | Skin Neoplasms |
| D009371 | Neoplasms by Site |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
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