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Improvement of retinal medical imaging opens new perspectives for exploring the retinal structures. Optical coherence spectral domain (SD-OCT), which has been widely used in the last ten years, is certainly the most advanced device. In the analysis of patients without retinal disease using SD-OCT, granulations in the interdigitation area were observed. These granulations have never been described with this device. They could correspond either to the degradation products of the external segments of the photoreceptors or to melanosomes. A descriptive study of these granulations at different examination times and in different lighting situations would allow us to obtain essential information for a better understanding of this area. Based on the results, larger studies could explore this area more finely in retinal pathologies involving dysfunctions of photoreceptors or of the pigmentary epithelium.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Normal conditions of light exposure | Other | Spectral Domain Optical Coherence Tomography (SD-OCT): Five SD-OCTs will be produced under the same lighting conditions (photopic).
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| Light variations | Other | Spectral Domain Optical Coherence Tomography (SD-OCT): Five SD-OCT will be performed:
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Spectral Domain Optical Coherence Tomography | Device | Five SD-OCTs will be performed with various conditions of enlightenment. |
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| Measure | Description | Time Frame |
|---|---|---|
| Variation of the number of hyperreflective granulations in the interdigitation area according to time and enlightenment | 1 hour after baseline |
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Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Fondation Ophtalmologique A. de Rothschild | Paris | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33393736 | Result | Mathis T, Vasseur V, Zuber K, Arej N, Loria O, Kodjikian L, Sennlaub F, Mauget-Faysse M. Light-induced modifications of the outer retinal hyperreflective layers on spectral-domain optical coherence tomography in humans: an experimental study. Acta Ophthalmol. 2021 Nov;99(7):765-772. doi: 10.1111/aos.14723. Epub 2021 Jan 4. |
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