Comparison of Stereotactic Body Radiation Therapy (SBRT) and repeated transarterial chemoembolization (TACE) for Hepatocellular Carcinoma (HCC)as a Local Salvage Treatment after first incomplete TACE

The aim of this study is to evaluate the effect of SBRT after first incomplete TACE.

In HCC patients with incomplete TACE response, repeated TACE did not showed good response. In this case, SBRT could have better results than TACE.

Inclusion Criteria:

• Age >18 years
• Eastern cooperative oncology group(ECOG) score 0 to 2
• Primary HCC
• HCC (single nodule ≤ 7 cm or max 3 nodules ≤ 3 cm)
• Child-Turgottei-Pugh A or B
• Unresectable lesion or medically contraindicated surgery or a case in which surgery was declined.
• No evidence of radiologically definable major vascular invasion or extrahepatic disease
• Previously incomplete TACE with radiologically defined residual disease after first TACE
• Informed consent

Exclusion Criteria:

• Prior TACE to the target lesion
• Contraindication to receiving radiotherapy or TACE
• Decompensated liver cirrhosis
• Extrahepatic mets
• Pregnancy
• Patients with other cancers

open labled