GLP-1 Response in Women With PCOS and Prediabetes

Reduced GLP-1 Response is Associated With Prediabetes in Women With Adverse Metabolic Phenotype of PCOS Independently of BMI

Women with PCOS are more prone to obesity which exacerbates insulin resistance, the abdominal fat disposition and metabolic risk of these patients. With development of obesity these women have high conversion rate from normal glucose tolerance to impaired glucose tolerance and in turn to type 2 diabetes.

Glucagon-like peptide 1 (GLP-1) is involved in body weight maintenance. Beside energy balance it is also involved in glucose homeostasis. Functional deficit in GLP-1 facilitates obesity. We investigated the link between the concentration of incretin hormones and glucose homeostasis, metabolic complications and the distribution of body composition in obese women with PCOS.

Inclusion Criteria:

• 18 years old to menopause
• polycystic ovary sindrome (NICHD criteria)
• BMI of 30 kg/m2 or higher

Exclusion Criteria:

• type 1 or type 2 diabetes mellitus
• Cushing's syndrome or congenital (non-classic) adrenal hyperplasia
• personal or family history of MEN 2
• the use of medications known or suspected to affect reproductive or metabolic functions
• the use of statins within 90 days prior to study entery