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Challenges recruiting healthy, sedentary 65-75 year old males
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| Name | Class |
|---|---|
| Royal Devon and Exeter NHS Foundation Trust | OTHER |
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As people grow older skeletal muscle gradually becomes smaller and weaker, causing reduced mobility and quality of life. To understand and reverse this negative process investigators need to find new ways of improving the ability of muscle to perform physical activity. There is some evidence that supplements may improve how the mitochondria work, and investigators want to explore this idea in more detail. This is possible by measuring how the muscles work and respond to exercise before and after taking the supplement alongside an aerobic (i.e. cycling) and resistance (i.e. weight lifting) exercise programme. This will give us the basic information investigators would need to see if this is a useful idea.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Acipimox plus exercise training | Experimental | The active supplement will contain the prescription drug Acipimox (250 mgs) , a nicotinic acid precursor traditionally used to lower blood lipid levels. The supplement will be administered 3 times per day, for 6 weeks. |
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| Placebo plus exercise training | Placebo Comparator | The placebo supplement will contain only cellulose microcrystalline. This is an inert substance widely used in many pill and tablet formulations. It is an insoluble fibre and is not absorbed into the blood stream therefore is unlikely to cause toxicity when taken orally. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Acipimox | Dietary Supplement | Acipimox plus exercise training: Oral supplement containing Acipimox 250mgs as the active ingredient in blinded label tablet form. |
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| Measure | Description | Time Frame |
|---|---|---|
| Change in mitochondrial function | Mitochondria will be extracted from muscle samples immediately post-biopsy (biopsies taken baseline, week 3 and week 6) and analysed for content and subsequently for oxidative respiratory function using the Oroboros technique, and maximal rates of Adenosine Triphosphate (ATP) production. | Baseline, 3 weeks, 6 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Chronic changes in habitual muscle protein synthetic rates | Baseline saliva samples then frequent saliva samples over 6 weeks following oral ingestion of the stable isotope deuterium oxide (D2O, or 'heavy water') will be analysed by gas-chromatography-pyrolysis-isotope ratio mass-spectrometry. analysis. Muscle samples collected at baseline, 3 weeks, 6 weeks will also be analysed by gas-chromatography-pyrolysis-isotope ratio mass-spectrometry |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Colleen Deane, PhD | University of Exeter | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| NIHR Exeter Clinical Research Facility | Exeter | Devon | EX2 5DW | United Kingdom |
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| ID | Term |
|---|---|
| C027696 | acipimox |
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| Placebo | Dietary Supplement | Alternate unilateral resistance and aerobic exercise training will also be performed 5 times per week for 6 weeks. |
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| Baseline, 3 weeks and 6 weeks |