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| ID | Type | Description | Link |
|---|---|---|---|
| 2016-A01608-43 | Other Identifier | ID-RCB number, ANSM |
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COVID
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This study evaluates the effect of a unique session of inhibitory rTMS (cTBS) over the contralesional posterio parietal cortex (PPC) on the spatio-temporal parameters of a pointing movement performed by stroke patients with their paretic upper limb. It will also assess the effects on the resting motor threshold of both hemispheres and on parietopremotor connectivity.
To achieve theses aims, the real cTBS stimulation will be randomly counterbalanced with a SHAM stimulation (in a second session) in a crossover design. Assessments will be performed before and after each stimulation session.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| cTBS stimulation | Active Comparator | continuous theta-burst TMS stimulation (1200 pulses, 50Hz, separated in two sequences of 600 pulses) |
|
| SHAM stimulation (placebo) | Sham Comparator | SHAM stimulation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| repeated transcranial magnetic stimulation continuous theta-burst stimulation | Device | cTBS |
|
| Measure | Description | Time Frame |
|---|---|---|
| Time of movement during the pointing movement | Time between the initiation of the movement and the reaching of the target | 30 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Reaction time (time between the go signal and th onset of the movement) | temporal parameters of pointing movements | 30 minutes |
| Response time (time between the go signal and the reaching of the target) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Etienne Allart, MD | University Hospital, Lille | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hôpital Swynghedauw, CHU lille | Lille | 59037 | France |
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| SHAM repeated transcranial magnetic stimulation | Device | SHAM stimulation |
|
temporal parameters of pointing movements
| 30 minutes |
| Peak velocity of the hand during the pointing movement | pak velocity in m/s | 30 minutes |
| smoothness (number of units of movement during the pointing movement), | Spatial parameters of pointing movements | 30 minutes |
| Linearity (ration between the length of the trajectory of the hand and the linear distance between the initial position of the hand and the target) | Spatial parameters of pointing movements | 30 minutes |
| Detection of mirror movements with the healthy upper limb | EMG detection | 30 minutes |
| Primary motor cortex excitability of both motor cortices | Resting motor threshold of lesioned and non-lesioned hemispheres | 30 minutes |
| Parietomotor connectivity in the contralesional hemisphere | Assessed by a paired-pulse TMS protocol (see Allart et al. 2017 for more details) | 30 minutes |
| Spatial bias | Line bisection test | 30 minutes |
| ID | Term |
|---|---|
| D020521 | Stroke |
| D010291 | Paresis |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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