The purpose of this study was to compare the safety and efficacy of CT-guided needle guidance using stereotaxic unit, navigation versus conventional biopsy technique for the patients scheduled to undergo percutaneous pulmonary nodule biopsy.

Inclusion Criteria:

• Patient with localized lesions such as pulmonary nodules on chest x-ray, CT or PET CT
• Histopathologic examination is necessary if lung lesion is unknown
• Histologic findings affect the disease stage or treatment plan
• If the investigator decides to perform a percutaneous lung biopsy because the biopsy or diagnosis through the bronchoscopy is not possible or has low risk-benefit
• Patient who have consented to contraception during the period of clinical trial participation (one month after the procedure)
• Patient who voluntarily agree to participate in this clinical trial and are willing to comply with the protocol

Exclusion Criteria:

• Patient with pulmonary function insufficiency
• Patient who has difficulty in self-breathing (e.g, breathing through oxygen breathing apparatus)
• Patient with Uncontrolled coagulation disorders (INR > 1.3 or Blood platelet count < 50,000/µl)
• Patient with allergy to CT contrast agent
• Patient under 19 years old or over 80 years old
• Pregnant or lactating
• Patient with uncontrollable systemic disease (e.g, uncontrolled hypertension, uncontrolled cardiovascular disease, etc.)
• Patient who currently participating or has participated in other clinical trials within 30 days of the screening date
• If it is judged inappropriate to participate in this clinical trial under the judgment of the investigator