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The goal of this study is to determine whether survivors of Legionnaires' disease suffer smell loss. A quantitative olfactory test will be performed by the participants. Such testing will require approximately 20-30 minutes of the participant's time. The participants will take the University of Pennsylvania Smell Identification Test (UPSIT), a scratch-and-sniff test to assess their ability to identify odors in a forced- choice format. Volunteers will also complete a questionnaire asking personal history, demographic questions, and medical history.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Legionnaires' Disease Volunteers | Volunteers who have been diagnosed/survivors of Legionnaire's Disease |
| |
| Healthy Volunteers | Volunteers who are healthy. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| The University of Pennsylvania Smell Identification Test (UPSIT) | Other | This standardized test, the most widely used olfactory test in the world, is derived from basic psychological test measurement theory and focuses on the comparative ability of subjects to identify odorants at the suprathreshold level. The UPSIT consists of four envelope-sized booklets, each containing ten "scratch and sniff" odorants embedded in 10- 50-µm polymer microcapsules positioned on brown strips at the bottom of the pages of the booklets. |
| Measure | Description | Time Frame |
|---|---|---|
| Score on the University of Pennsylvania Smell Identification Test | The number of correct odor identification responses out of 40 from the standardized University of Pennsylvania Smell Identification Test. The total number of correct responses will then be compared to standard norms of correct responses based on demographic information such as age and sex. Comparing the scores to the standard norms collected will indicate whether a volunteer is normosmic, hyposmic, or anosmic. | 20-30 Minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Questionnaire Responses | These are various demographic and medical history questions regarding exposure to Legionella Pneumonia and current experiences post diagnosis and treatment. | 20-30 Minutes |
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Inclusion Criteria:
Exclusion Criteria:
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The subjects to be tested in this study represent two different populations. The first is a group of who have survived Legionnaires' disease. The second group will be healthy men and women over the age of 18 years.
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| Name | Affiliation | Role |
|---|---|---|
| Richard L Doty, PhD | University of Pennsylvania | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | United States |
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| ID | Term |
|---|---|
| D007877 | Legionnaires' Disease |
| ID | Term |
|---|---|
| D007876 | Legionellosis |
| D016905 | Gram-Negative Bacterial Infections |
| D001424 | Bacterial Infections |
| D001423 | Bacterial Infections and Mycoses |
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|
| D007239 | Infections |
| D012141 | Respiratory Tract Infections |
| D012140 | Respiratory Tract Diseases |