Use of Prothrombin Complex Concentrate in Patients Admitted in Emergency Care Units for Severe Bleeding While Receiving Oral Anticoagulants

Administration of PCC in Patients Admitted in Emergency Care Units for Severe Bleeding While Receiving Oral Anticoagulants: Impact of an Expert ECRF on Adherence to Rules of Proper Use and Outcome

The study is assessing the impact of an expert eCRF on the management of severe bleeding in the administration of Prothrombin Complex Concentrate in patients treated with oral anticoagulants and adherence to recommendations or experts' consensus

Inclusion Criteria:

• Adult patients (≥ 18 years old)

• Receiving oral anticoagulants (VKA or DOAC)

• With a severe bleeding episode meeting at least one of the following criteria

• External hemorrhage which cannot be controlled by usual means or

• Hemodynamic instability: SBP < 90 mmHg or SBP decrease

  • 40 mmHg from usual SBP or mean BP < 65 mmHg or any sign of shock or

• Patient requiring a hemostatic procedure in emergency:

surgery, interventional radiology, endoscopy or

• Need for transfusion of packed red blood cells or

• Hemorrhage jeopardizing the vital or functional prognosis:

  e.g. intracranial hemorrhage, intraspinal hemorrhage, intraocular or retro-ocular hemorrhage, hemothorax, hemoperitoneum, retroperitoneal hemorrhage, hemopericardium, deep muscle hematoma or compartment syndrome, acute digestive hemorrhage, hemarthrosis.

• Admitted in the participating emergency service

• Accepting the collection of his/her own health-related data

Exclusion Criteria:

• Patient participating in another interventional study
• Pregnant or nursing woman
• Patient under supervision or legal guardianship