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| ID | Type | Description | Link |
|---|---|---|---|
| Biobank Pearl AAA | Registry Identifier | Biobank Pearl AAA |
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First aim: PARIS study
The main aim of the current study is to determine the association between abdominal aortic aneurysm (AAA) progression and the evolution of proteases and cytokines levels.To achieve this aim, we will prospectively collect blood, aortic tissue, patient data, and imaging data. Aortic tissue will only be obtained when patients undergo conventional open repair. The other biomaterials will be collected during regular patient follow-up visits, with a maximum frequency of once per year.
Second aim: Pearl AAA biobank
For future research purposes, a new biobanking infrastructure will be created to collect and store additional blood and urine samples in a biobank. This biobank will be embedded within the infrastructure of the 'Parelsnoer Institute' (PSI) and will be called Pearl AAA. The Pearl AAA will be established in the extension of the PARIS study
The PARIS study aims to determine the correlation between AAA progression (growth or rupture) and the evolution of serum levels of proteases and cytokines over time. A repeated measures analysis will be done to use all longitudinal data available.
The Pearl AAA biobank will be established to enable the PARIS study, but also aims to facilitate future research. Such future research should fall under the scientific aims of the Pearl AAA, which are:
The 'Parelsnoer Institute' will facilitate the biobank Pearl AAA with certain aspects such as, but not limited to the following:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Asymptomatic AAA | These patients will be included while their AAA is asymptomatic and while they are under surveillance by their vascular surgeon. | ||
| Acute AAA | These are the patients that are included while they presented in the participating hospitals because either a symptomatic or ruptured AAA. For this group, a different recruitment procedure exists which has been approved by the appropriate medical ethical committee. | ||
| Repaired AAA | These patients are included while they already had had AAA repair (both elective and emergency repair). |
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| Measure | Description | Time Frame |
|---|---|---|
| AAA growth | Growth of abdominal aortic aneurysm, measured on imaging made for clinical purposes | Up to 10 years of follow-up |
| AAA rupture | Rupture of an abdominal aortic aneurysm | Up to 10 years of follow-up |
| Death | All-cause mortality | Up to 10 years of follow-up |
| Evolution of serum levels of proteases | Repeated measurements analysis of serum levels of proteases in cohort of asymptomatic AAAs | a maximum of 1 measurement annually up to 10 years of follow-up |
| Evolution of serum levels of cytokines | Repeated measurements analysis of serum levels of cytokines in cohort of asymptomatic AAAs | a maximum of 1 measurement annually up to 10 years of follow-up |
| Protease levels in aortic tissue | Protease levels in aortic tissue | If open AAA repair is performed and aortic tissue is collected, protease levels will then be measured. This is a one-time measurement. |
| Cytokine levels in aortic tissue | Cytokine levels in aortic tissue | If open AAA repair is performed and aortic tissue is collected, cytokine levels will then be measured. This is a one-time measurement. |
| Measure | Description | Time Frame |
|---|---|---|
| Type of complications after AAA repair | Type of complications using methodology from the Dutch committee of the "Nederlandse Vereniging voor Heelkunde," named the "Landelijke Heelkunde Complicatie Registratie" as found on www.lhcr.nl | Will be measured up to 10 years after AAA repair is performed |
| Incidence of complications after AAA repair |
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Inclusion Criteria:
Exclusion Criteria:
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All adult patients with an abdominal aortic aneurysm who present themselves in the participating hospitals.
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| Name | Affiliation | Role |
|---|---|---|
| Ron Balm, MD PhD | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Leiden University Medical Center (LUMC) | Leiden | South Holland | 2333ZA | Netherlands | ||
| Department of Vascular Surgery, Amsterdam UMC, location AMC |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31375618 | Derived | Jalalzadeh H, Indrakusuma R, Blankensteijn JD, Wisselink W, Yeung KK, Lindeman JHN, Hamming JF, Koelemay MJW, Legemate DA, Balm R. Design and protocol of a comprehensive multicentre biobank for abdominal aortic aneurysms. BMJ Open. 2019 Aug 1;9(8):e028858. doi: 10.1136/bmjopen-2018-028858. |
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Researchers can initiate the procedure to request IPD for research that falls within the scientific scope of the biobank Pearl AAA.
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Depending on the specific study protocols that are submitted to the biobank Pearl AAA
Procedural criteria can be attained by contacting the researchers.
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| ID | Term |
|---|---|
| D017544 | Aortic Aneurysm, Abdominal |
| D012421 | Rupture |
| D001014 | Aortic Aneurysm |
| ID | Term |
|---|---|
| D000783 | Aneurysm |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D001018 | Aortic Diseases |
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Three types of biospecimens will be collected, depending on the clincial stage of the abdominal aortic aneurysm.
Blood:
EDTA plasma; Serum; Citrate plasma; EDTA for DNA; PAXgene for RNA.
Urine.
Aneurysm tissue
Number of complications after abdominal aortic aneurysm repair |
| Will be measured up to 10 years after AAA repair is performed |
| Amsterdam |
| 1105 AZ |
| Netherlands |
| D014947 |
| Wounds and Injuries |