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The aim of the present study is to quantify the dose and usage of sympathomimetics used in caesarean section.
Recent metaanalysis showed significantly reduced hypotension and bradycardia in patients undergoing caesarean section in spinal anesthesia when 5-hydroxytryptamine 3 receptor antagonists were used prophylactically.
Due to this fact in our clinic the standard procedure was changed. All patients for caesarean section receive Granisetron before spinal anesthesia.
The aim of the present study is to evaluate the usage and dose of sympathomimetics during spinal anesthesia.
Therefore the investigators will evaluate approximately 120 participants who received granisetron and 120 participants who did not receive 5-hydroxytryptamine 3 receptor antagonists.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| No Granisetron | 120 Patients prior to changes of intern standards of caesarean section. Before march 2017 no patient undergoing elective caesarean section received Granisetron as a matter of routine. |
| |
| With Granisetron | 120 Patients after changes of intern standards of caesarean section. After march 2017 all patient undergoing elective caesarean section received Granisetron as a matter of routine. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Granisetron Hydrochloride | Drug | Patients received Granisetron. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Sympathomimetics | Type of sympathomimetics during during the operation | 30 minutes starting with induction of spinal anesthesia. |
| Measure | Description | Time Frame |
|---|---|---|
| Sympathomimetics | Cumulative dose of sympathomimetics during during the operation | 30 minutes starting with induction of spinal anesthesia. |
| Volume substitution | Type of perioperative infused volume during the operation |
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Inclusion Criteria:
Exclusion Criteria:
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All patients who underwent spinal anesthesia for caesarean section in out clinic.
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| Name | Affiliation | Role |
|---|---|---|
| Kai Zacharowski, Prof. Dr. med. | Department of Anesthesia, Intensive Care Medicine and Pain Therapy | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Klinikum Goethe Universität Frankfurt am Main | Frankfurt am Main | Hesse | 60590 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30932170 | Derived | Raimann FJ, Baldauf HP, Louwen F, Jennewein L, Fischer D, Zacharowski K, Weber CF. Granisetron reduces the need for uterotonics but not sympathomimetics during cesarean delivery. Int J Gynaecol Obstet. 2019 Jun;145(3):361-366. doi: 10.1002/ijgo.12819. Epub 2019 Apr 15. |
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| ID | Term |
|---|---|
| D007022 | Hypotension |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D017829 | Granisetron |
| ID | Term |
|---|---|
| D053961 | Azabicyclo Compounds |
| D001372 | Aza Compounds |
| D009930 | Organic Chemicals |
| D007191 | Indazoles |
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| No Granisetron | Drug | Patients who did not receive Granisetron. |
|
| 30 minutes starting with induction of spinal anesthesia. |
| Volume substitution | Cumulative volume of perioperative infused volume during the operation | 30 minutes starting with induction of spinal anesthesia. |
| Haemotherapy | Type of haemotherapy. | 30 minutes starting with induction of spinal anesthesia. |
| Haemotherapy | Cumulative volume of haemotherapy. | 30 minutes starting with induction of spinal anesthesia. |
| Duration until first application of sympathomimetics | Duration until first administration of any kind of sympathomimetics. | 30 minutes starting with induction of spinal anesthesia. |
| Oxytocin | Duration until first administration of oxytocin. | 30 minutes starting with induction of spinal anesthesia. |
| Oxytocin | Cumulative dose of Oxytocin. | 30 minutes starting with induction of spinal anesthesia. |
| Uterotonic agents | Kind of uterotonic agents. | 30 minutes starting with induction of spinal anesthesia. |
| Uterotonic agents | Cumulative dose of uterotonic agents. | 30 minutes starting with induction of spinal anesthesia. |
| D011720 |
| Pyrazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D019086 | Bridged Bicyclo Compounds, Heterocyclic |
| D006572 | Heterocyclic Compounds, Bridged-Ring |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |