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The Freder1k-Study will identify infants who have a high genetic risk of type 1 diabetes.
Type 1 diabetes is a common chronic disease in childhood and is increasing in incidence. Type 1 diabetes is diagnosed by hyperglycemia often in combination with symptoms of weight loss, thirst, fatigue and frequent urination, sometimes with ketoacidosis. The clinical onset is preceded by an asymptomatic phase identified by serum multiple beta-cell autoantibodies. Neonates and infants who are at increased risk to develop multiple beta-cell autoantibodies and type 1 diabetes can now be identified using genetic markers. This provides opportunity for introducing early therapies to prevent beta-cell autoimmunity and type 1 diabetes.
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| Measure | Description | Time Frame |
|---|---|---|
| greater than 10% risk for multiple beta-cell autoantibodies/type 1 diabetes | increased risk will be identified by risk scores derived from SNPs | one-time testing before age 6 weeks |
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Inclusion Criteria:
Exclusion Criteria:
-
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The Freder1k-Study will identify infants who have a high genetic risk of type 1 diabetes.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Anette-Gabriele Ziegler | Contact | 0800-000 0018 | contact@gppad.org | |
| Christiane Winkler | Contact | 0049-89-31873745 | contact@gppad.org |
| Name | Affiliation | Role |
|---|---|---|
| Anette-Gabriele Ziegler | Helmholtz Zentrum München, IDF-1 | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Institut für Diabetesforschung, Helmholtz Zentrum München | Recruiting | Munich | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33163984 | Derived | Hippich M, Holthaus L, Assfalg R, Zapardiel-Gonzalo J, Kapfelsperger H, Heigermoser M, Haupt F, Ewald DA, Welzhofer TC, Marcus BA, Heck S, Koelln A, Stock J, Voss F, Secchi M, Piemonti L, de la Rosa K, Protzer U, Boehmer M, Achenbach P, Lampasona V, Bonifacio E, Ziegler AG. A Public Health Antibody Screening Indicates a 6-Fold Higher SARS-CoV-2 Exposure Rate than Reported Cases in Children. Med. 2021 Feb 12;2(2):149-163.e4. doi: 10.1016/j.medj.2020.10.003. Epub 2020 Oct 29. |
| Label | URL |
|---|---|
| GPPAD | View source |
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| ID | Term |
|---|---|
| D003922 | Diabetes Mellitus, Type 1 |
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| D004700 | Endocrine System Diseases |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |