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| Name | Class |
|---|---|
| National Cancer Institute (NCI) | NIH |
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This study is to help determine the most effective type or combination of treatments to offer patients seeking lung cancer screening who are smokers to help them reduce the number of cigarettes they smoke, or quit smoking. The investigators long term goal is to increase the benefits of lung cancer screening by providing a blue print of best practices for screening sites to deliver tobacco treatment to their patients who are smokers, in a way that does not add burden to screening site staff and increases the chances of patients quitting smoking.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Motivational Interviewing( MI) (Yes vs. No) | Experimental | Participants will receive two motivational informed cessation sessions; the first delivered face to faceor via telephone by the SC during the patient's initial lung cancer screening visit or during the shared decision making discussion or within about 1 week following their screening visit, and the second session delivered by telephone by the SC approximately 4 to 8 weeks after the first MI session. |
|
| Nicotine Replacement Therapy (NRT) Patch (Yes vs. No) | Experimental | Participants will receive 6 weeks of NRT patch with dosing dependent upon reported baseline cigarettes per day and written instructions to use the patch daily starting on date they mutually agreed upon with their site coordinator. Participants who smoke fewer than 10 cigarettes per day will receive 4-weeks of the 14mg patch (2 boxes), and 2-weeks of the 7mg patch (1 box). Those who smoke 10 or more cigarettes per day will receive 4-weeks of the 21mg patch (2 boxes) and 2-weeks of the 14mg patch (1 box). Participants will receive their study medications from their site coordinator on the day of their screening appointment or via mail from Arrowhead Promotion & Fulfillment. |
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| NRT Lozenge (Yes vs. No) | Experimental | Participants will receive will receive 6 packs of NRT 2mg lozenge and written instructions to use the lozenge PRN to help manage acute nicotine withdrawal. Participants will be instructed to use the NRT lozenges no more than every 1-2 hours as needed. Participants will receive their study medications from their site coordinator on the day of their screening appointment or via mail from Arrowhead Promotion & Fulfillment. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Motivational Interviewing (MI) | Behavioral | two counseling sessions |
|
| Measure | Description | Time Frame |
|---|---|---|
| number of patients who are tobacco abstinence | biochemical verification of smoking abstinence will be conducted Consistent with Intent to Treat, unless self reported smoking abstinence is biochemically verified, (<3 ng/ml for mailed salivary cotinine assay) for participants who fail to return the saliva sample, the cessation outcome will be considered non-abstinent. | 6 months following study enrollment |
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Inclusion Criteria:
Site Eligibility (as per SC self-report)
& Must be designated as an American College of Radiology (ACR) designated lung cancer screening site
Exclusion Criteria:
Patient (as per self-report)
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| Name | Affiliation | Role |
|---|---|---|
| Jamie Ostroff, PhD | Memorial Sloan Kettering Cancer Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Southern California (Data Collection Only) | Los Angeles | California | 90033 | United States | ||
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35978334 | Derived | Ostroff JS, Shelley DR, Chichester LA, King JC, Li Y, Schofield E, Ciupek A, Criswell A, Acharya R, Banerjee SC, Elkin EB, Lynch K, Weiner BJ, Orlow I, Martin CM, Chan SV, Frederico V, Camille P, Holland S, Kenney J. Study protocol of a multiphase optimization strategy trial (MOST) for delivery of smoking cessation treatment in lung cancer screening settings. Trials. 2022 Aug 17;23(1):664. doi: 10.1186/s13063-022-06568-3. |
| Label | URL |
|---|---|
| Memorial Sloan Kettering Cancer Center | View source |
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The investigators have chosen to conduct a full factorial experimental design.
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| Message Framing (Gain vs. Loss) | Experimental | Overall, a robust body of health communication literature demonstrates that gain-framed messages may be more effective than loss-framed or non-framed (neutral) messages for encouraging smoking cessation. In other words, quitting messages that promote smoking cessation are more persuasive if they emphasize the benefits of quitting (gain-framed) rather than the risks (loss-framed) of persistent smoking (25, 26). Included with the written communication of their LDCT-LCS results, participants will receive a printed individualized quitting message that emphasizes either the benefits of quitting (gain-framed) or the risks of continuing to smoke (loss-framed). |
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| Nicotine Replacement Therapy (NRT) | Drug | receive 6 weeks of NRT patch with dosing dependent upon reported baseline cigarettes per day |
|
| Nicotine Lozenge | Drug | 6 packs of NRT 2mg lozenge |
|
| Message Framing | Behavioral | health communication literature and quitting messages |
|
| saliva sample | Other | saliva samples from those reporting abstinence and analyze samples |
|
| John Muir Health |
| Walnut Creek |
| California |
| 94598 |
| United States |
| WellStar Health System | La Grange | Georgia | 30240 | United States |
| Rush University Medical Center | Chicago | Illinois | 606012 | United States |
| Riverside Healthcare | Kankakee | Illinois | 60901 | United States |
| St. Mary Medical Center, Community Healthcare System | Crown Point | Indiana | 46307 | United States |
| MercyOne Des Moines Medical Center (Data Collection Only) | Des Moines | Iowa | 50314 | United States |
| Maine Medical Center Cancer Institute | Scarborough | Maine | 04074 | United States |
| Henry Ford Hospital (Data collection only) | Detroit | Michigan | 48202 | United States |
| Munson Healthcare | Traverse City | Michigan | 49684 | United States |
| NYU Winthrop Hospital | Mineola | New York | 11501 | United States |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | United States |
| Weill Cornell Medical Center | New York | New York | 10065 | United States |
| Montefiore Medical Center (Data Collection Only) | The Bronx | New York | 10467 | United States |
| Carolinas Healthcare System Blue Ridge | Morganton | North Carolina | 28655 | United States |
| Fairfield Medical Center | Lancaster | Ohio | 43130 | United States |
| Legacy Health | Portland | Oregon | 97210 | United States |
| Temple University | Philadelphia | Pennsylvania | 19140 | United States |
| ID | Term |
|---|---|
| D016540 | Smoking Cessation |
| ID | Term |
|---|---|
| D015438 | Health Behavior |
| D001519 | Behavior |
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| ID | Term |
|---|---|
| D062405 | Motivational Interviewing |
| D000095488 | Nicotine Replacement Therapy |
| D061485 | Tobacco Use Cessation Devices |
| ID | Term |
|---|---|
| D037001 | Directive Counseling |
| D003376 | Counseling |
| D008605 | Mental Health Services |
| D004191 | Behavioral Disciplines and Activities |
| D006296 | Health Services |
| D005159 | Health Care Facilities Workforce and Services |
| D004358 | Drug Therapy |
| D013812 | Therapeutics |
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