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Central retinal artery occlusions (CRAO) are the equivalent of an ischemic stroke at the retinal level. They share the same risk factors and common pathology. The diagnosis of a CRAO is clinically based on the sudden occurrence of a decrease in deep visual acuity with fundamentally signs of reactive ischemia.
Small studies have highlighted the value of cerebral MRI (Magnetic Resonance Imaging) in CRAO with almost 25% of ischemic strokes found on diffusion sequences and the demonstration of a correlation between anomalies in diffusion sequence and the probability of a pathology with a high risk of recurrence (carotid stenosis or emboligenic cardiopathy). But there are usually few radiological signs that allow a direct positive diagnosis of CRAO, an etiologic diagnosis or a prognosis. This descriptive study will focus on CRAO at the diagnostic and post-treatment phases in the short and medium term, in order to (i) identify imaging etiologic signs of CRAO with specific sequences from a 3 Tesla MRI, (ii) identify positive diagnostic signs of CRAO with the same specific sequences, (iii) correlate these signs with the visual prognosis one month after the CRAO.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Additional MRI sequences | Device | Patients will be hospitalized for suspicion of CRAO. An "optimized" MRI will be performed with specific sequences: 3D T1 MSDE (Motion Sensitized Driven Equilibrium) "dark blood"; 3D Optimized diffusion centered on the optic nerves; 3D PD T1 after injection. A consultation of ophthalmology and a control MRI will be carried out one month after the CRAO. Again, specific sequences will be added: 3D T1 MSDE (Motion Sensitized Driven Equilibrium) "dark blood"; 3D Optimized diffusion centered on the optic nerves; DTI (Diffusion Tensor Imaging); 3D PD T1 after injection. |
| Measure | Description | Time Frame |
|---|---|---|
| Contrast enhancement of the ophthalmic artery | Binary variable (yes/no) | Baseline |
| Presence of a thrombus | Binary variable (yes/no) | Baseline |
| Presence of an arterial stenosis of the supra aortic trunks | Binary variable (yes/no) | Baseline |
| Hypersignal of the ophthalmic artery in diffusion | Binary variable (yes/no) | Baseline |
| Restriction of the apparent diffusion coefficient (ADC) at the optic nerve level and at the papilla level | Binary variable (yes/no) | Baseline |
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Inclusion Criteria:
Exclusion Criteria:
- Contraindications to 3 Tesla MRI
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Adult patients hospitalized for CRAO ≤ 48 hours.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Fondation Ophtalmologique A. de Rothschild | Paris | France |
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| ID | Term |
|---|---|
| D015356 | Retinal Artery Occlusion |
| D004194 | Disease |
| ID | Term |
|---|---|
| D012164 | Retinal Diseases |
| D005128 | Eye Diseases |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
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| D002318 |
| Cardiovascular Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |