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Preeclampsia is a systemic pregnancy disorder and is associated with an increased cardiovascular risk later in life. This study will characterize myocardial tissue in patients after preeclampsia compared to controls and investigate potential functional and structural changes in the heart of preeclamptic women primarily with two methods: cardiovascular magnetic resonance imaging and echocardiography. A comparison between these two methods, where appropriate, is also envisaged.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PE | Women with a history or preeclampsia, between 18 - 50 years of age, 0.5 - 20 years postpartum | ||
| Control | Age-matched women without any birth complications, between 18 - 50 years of age, 0.5 - 20 years postpartum |
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| Measure | Description | Time Frame |
|---|---|---|
| any structural or functional change of the heart (combined outcome) | Combined outcome: myocardial fibrosis, edema, fat infiltrates, inflammation, reduced ejection fraction, hypertrophy | 0.5 - 20 years after delivery |
| Measure | Description | Time Frame |
|---|---|---|
| myocardial fibrosis | 0.5 - 20 years after delivery | |
| myocardial edema | 0.5 - 20 years after delivery | |
| myocardial fat infiltrates |
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Inclusion Criteria:
Exclusion Criteria:
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Women between 18 and 50 years of age, 0.5 - 20 years postpartum either with preeclampsia diagnosis during index pregnancy or without pathological findings. Controls are matched to cases based on age and BMI.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Experimental and Clinical Research Center (ECRC) | Berlin | 13125 | Germany |
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| ID | Term |
|---|---|
| D011225 | Pre-Eclampsia |
| ID | Term |
|---|---|
| D046110 | Hypertension, Pregnancy-Induced |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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| 0.5 - 20 years after delivery |
| myocardial inflammation | 0.5 - 20 years after delivery |
| myocardial hypertrophy | 0.5 - 20 years after delivery |
| reduced ejection fraction | 0.5 - 20 years after delivery |