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This pilot study will explore whether treatment of eosinophilic inflammation in the esophagus is associated with an improved distensibility of the esophagus. Furthermore, previous studies of the esophagus using EndoFlip only measured distensibility of the distal esophagus, specifically the distal esophagus and esophagogastric junction. Eosinophilia in EoE has been demonstrated to affect both upper, middle and lower esophagus. The aim is to measure distensibility both proximal and distal, before and after treatment.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Eosinophilic Esophagitis patients | PPI treatment |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| endoflip | Diagnostic Test | Resolution of esophageal eosinophilia by a 2-month course of high dose PPI in patients will lead to improvement in esophageal distensibility, and thus should produce improvement in dysphagia symptoms. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Esophageal Distensibility before and after treatment | 1. Measure the changes in esophageal distensibility before and after treatment with PPI in patients with esophageal eosinophilia | 2 months |
| Measure | Description | Time Frame |
|---|---|---|
| Change in eosinophilia or the number of eosinophils | 4. To correlate changes of esophageal mucosa eosinophilia with changes of lumen distensibility in the different segments of the esophagus | 2 months |
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Inclusion Criteria:
1. Presence of eosinophilia on esophageal biopsy, defined as a peak count of > 15 eosinophils per high power field (HPF) on light microscopy based on biopsies from at least 2 of the 3 biopsy segments (upper, middle and distal esophagus)
Exclusion Criteria:
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Patients presenting to the clinic and endoscopy who are undergoing endoscopy with endoflip
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Maureen Schilling | Contact | maschi@iu.edu | ||
| Lainna Cohen | Contact | 3172780621 | larcohen@iu.edu |
| Name | Affiliation | Role |
|---|---|---|
| Akiro Saito, MD | Indiana University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Indiana University Health University Hospital | Recruiting | Indianapolis | Indiana | 46202 | United States |
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| ID | Term |
|---|---|
| D057765 | Eosinophilic Esophagitis |
| ID | Term |
|---|---|
| D004941 | Esophagitis |
| D004935 | Esophageal Diseases |
| D005767 | Gastrointestinal Diseases |
| D004066 | Digestive System Diseases |
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| Indiana University | Recruiting | Indianapolis | Indiana | 46202 | United States |
| D005759 |
| Gastroenteritis |
| D004802 | Eosinophilia |
| D007960 | Leukocyte Disorders |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D006969 | Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |