Determination of Tissue Transit Time (TTT) as a parameter with high prognostic value to predict the functional course of the differential renal function and the development of the differential renal function after pyeloplasty

The ureteropelvic junction obstruction occurs in around 13% of children with antenatally diagnosed hydronephrosis. It remains a controversial topic what prognostic factors may be predictive for deterioration of the differential renal function.

The tissue transit time (TTT) in the 99mTc- MAG3 diuretic renogram seems to be a predictive factor for the deterioration of the differential renal function in these patients. We therefore analyze the tissue transit time in the 99mTc- MAG3 diuretic renogram in a prospective multicenter observational study to determine it as a prognostic and diagnostic factor. Aim of the study is to differentiate which children could be treated conservatively and which will benefit from operative pyeloplasty

Inclusion Criteria:

• unilateral, isolated hydronephrosis >= grade III (SFU)
• age <= 3 months

Exclusion Criteria:

• associated malformation of the urogenital tract
• global kidney insufficiency proven by creatinine examination
• prematurity
• no informed consent

Term born infants <= 3 months of age with a unilateral, insolated hydronephrosis >= grade III (SFU)