Serum and Peritoneal Concentration in Antibiotics During the Surgical Management of Peritonitis: SPAC
Serum and Peritoneal Concentration in Antibiotics During the Surgical Management of Peritonitis: SPAC
SPAC is a pilote monocentric prospective study about peritonitis and antibiotics pharmacokinetic and pharmacodynamic. The investigators will included 50 patients during 2 years in the University Hospital of Nancy.
The aim of this study is to determine if the beta-lactam dosages recommended by the guidelines for management of intra-abdominal infections (published by the Société française d'anesthésie et de réanimation (Sfar) in december 2015) permitted the achievement of adequatly serum and peritoneal concentrations in the medical and surgical management of peritonitis.
The investigators will collected 3 pairs of serum and peritoneal fluid samples at 3 different times: peritoneal incision, arrival in ICU and 24 hours after admission in ICU in order to compare the concentrations and the minimal inhibitor concentration of bacteria.
The hypothesis is that of a serum and peritoneal antibiotic under dosage.
Inclusion Criteria:
Exclusion Criteria:
e.novy@chru-nancy.fr+33 3157437
m.siaghy@chru-nancy.fr+33 3155276