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| ID | Type | Description | Link |
|---|---|---|---|
| 2017-A01504-49 | Other Identifier | ANSM |
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The aim of the study is to describe an immune activation profile of people at risk of insulin resistance based on a wide range of markers which will allow easy identification of patients at risk.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients aged 55-60 |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blood test | Other | 6ml blood sample taken |
|
| Measure | Description | Time Frame |
|---|---|---|
| Cluster of Differentiation 4 (CD4+) T cell subpopulations | immunosenescence; number/mm3 | Day 0 |
| Cluster of Differentiation 8 (CD8+) T cell subpopulations | immunosenescence; number/mm3 | Day 0 |
| B cell subpopulations | flow cytometry | Day 0 |
| Natural killer (NK) cell subpopulations | immunosenescence; number/mm3 | Day 0 |
| sCD14 level | ng/ml, enzyme-linked immunosorbent assays (ELISA) | Day 0 |
| 16 ribosomal ribonucleic acid (rRNA) levels | polymerase chain reaction (PCR); copies/µl | Day 0 |
| lipopolysaccharide (LPS)-binding protein level | ELISA; µg/mL | Day 0 |
| Intestinal Fatty Acid Binding Protein level | ELISA; pg/mL | Day 0 |
| Total cholesterol | mM/L |
| Measure | Description | Time Frame |
|---|---|---|
| Prevalence of insulin and metabolic syndrome | % subjects | Day 0 |
| Link between immune activation profile and other features of metabolic syndrome | logistic regression of individual markers |
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Inclusion Criteria:
Exclusion Criteria:
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Volunteers aged between 55-69
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Nimes | Nîmes | 30029 | France | |||
| Centre d'examen de santé de la Sécurité Sociale de Nîmes |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33257766 | Result | Cezar R, Winter A, Desigaud D, Pastore M, Kundura L, Dupuy AM, Cognot C, Vincent T, Reynes C, Dunyach-Remy C, Lavigne JP, Sabatier R, Le Merre P, Maggia E, Corbeau P. Identification of distinct immune activation profiles in adult humans. Sci Rep. 2020 Nov 30;10(1):20824. doi: 10.1038/s41598-020-77707-6. |
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| ID | Term |
|---|---|
| D007333 | Insulin Resistance |
| D024821 | Metabolic Syndrome |
| ID | Term |
|---|---|
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D006403 | Hematologic Tests |
| ID | Term |
|---|---|
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D008919 | Investigative Techniques |
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| Day 0 |
| High Density Lipoprotein | mM/L | Day 0 |
| Low Density Lipoprotein | mM/L | Day 0 |
| fasting glycemia | Day 0 |
| fasting insulinemia | mIU/L | Day 0 |
| γ-glutamyl transpeptidase level | Day 0 |
| glutamic pyruvic transaminase | Day 0 |
| hip circumference | cm | Day 0 |
| waist circumference | cm | Day 0 |
| minimal arterial tension | mmHg | Day 0 |
| maximal arterial tension | mmHg | Day 0 |
| Cluster of Differentiation 163 (CD163) level | ng/ml, enzyme-linked immunosorbent assays (ELISA) | Day 0 |
| soluble tumor necrosis factor-alpha receptor I (sTNFRI) level | ng/ml, enzyme-linked immunosorbent assays (ELISA) | Day 0 |
| soluble endothelial protein C Receptro (sEPCR) level | ng/ml, enzyme-linked immunosorbent assays (ELISA) | Day 0 |
| tissue plasminogen activator (tPa) level | ng/ml, enzyme-linked immunosorbent assays (ELISA) | Day 0 |
| Day 0 |
| Immune activation linked to the profile | logistic regression | Day 0 |
| Nîmes |
| France |