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| ID | Type | Description | Link |
|---|---|---|---|
| 2016-A01601-50 | Other Identifier | ID-RCB |
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To compare in vivo platelet and leukocyte activation and phenotype before and after Left ventricular assist device (LAVD) implantation
The present study plan to investigate platelet activation in vivo using a variety of biomarkers previously identified as sensitive to high shear stress in patients with severe aortic valve stenosis before and after trans arterial valve replacement. As one of the best biomarker is a high degree of platelet-leukocyte interactions, the study will study in parallel leukocytes activation/differentiation. These parameters will be compared at 3 time-points, before and after LAVD implantation in ambulatory patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| LAVD implantation | Experimental | Ten patients before and after LAVD implantation had blood sampling |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blood sampling | Other | Three venous blood sampling before the left ventricular assist device implantation and 1 and 2 months after implantation in ambulatory patients. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Platelet activation | To compare platelet activation in vivo, using a composite criteria determinated by variety of biomarkers of activation analysed by flow cytometry and enzyme-linked immunosorbent assay (ELISA) | Month 2 after LAVD implantation |
| Measure | Description | Time Frame |
|---|---|---|
| Level of circulating platelet-leukocyte conjugate | To determine the level of circulating platelet-leukocyte conjugate by flow cytometry | Month 2 after LAVD implantation |
| Changes in leukocyte phenotype |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Pierre SIE, MD, PhD | University Hospital of Toulouse, Rangueil, Hematology laboratory | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital | Toulouse | France |
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| ID | Term |
|---|---|
| D006333 | Heart Failure |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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To determine the leukocyte phenotype which is a composite criteria analysed by flow cytometry, ELISA and lipidaemic analysis
| Month 2 after LAVD implantation |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |