Severe isolated Traumatic Brain injury patients with serum fibrinogen level under 200 mg/dl that receive Fibrinogen concentrate after common emergency resuscitation. Instruction:

1. Airway control & breathing.
2. Circulation (Serum therapy, Epinephrine,Packed cell, FFP and ...).
3. Fibrinogen Concentrate(IV injection): Each vial contains 1gr fibrinogen concentrate. Fibrinogen concentrate will be given until serum fibrinogen level riches to 200 mg/dl.

Dose (mg/kg body weight) = ([Target level (mg/dL) - measured level (mg/dL)])/(1.7 (mg/dL per mg/kg body weight))

Severe isolated Traumatic Brain injury patients with serum fibrinogen level under 200 mg/dl that receive common emergency resuscitation. Instruction:

1. Airway control & breathing.
2. Circulation (Serum therapy, Epinephrine,Packed cell, FFP and ...).

RiaSTAP, Fibrinogen Concentrate (Human) is a human blood coagulation factor indicated for the treatment of acute bleeding episodes.

Dose (mg/kg body weight) =

([Target level (mg/dL) - measured level (mg/dL)])/(1.7 (mg/dL per mg/kg body weight))

Mortality rate after injection of fibrinogen concentrate.

Average of serum fibrinogen level in iTBI patient.

The need to packed cell, FFP, Platelete.

like DVT, PTE, MI.by measurement of serum D-dimer for DVT and PTE and serum Troponin C for MI.