Fibrinogen Concentrate in Isolated Traumatic Brain Injury

Early Fibrinogen Concentrate in Isolated Traumatic Brain Injury and the Effect on Post Bleeding & Complications

Fibrinogen is a unique precursor of fibrin and cannot be compensated for by other coagulation factors. If plasma fibrinogen concentrations are insufficient, hemostatic clots cannot be formed with the appropriate firmness. In severe traumatic brain injury(TBI) patients, plasma fibrinogen concentrations decrease earlier and more frequently than other coagulation factors,predicting massive bleeding and death.

The purpose of this study is to try early injection of fibrinogen concentrate in severe isolated traumatic brain injury and investigation the effect of it on post bleeding and complications.

Inclusion Criteria:

• Patients with severe isolated traumatic brain injury.

Exclusion Criteria:

• Severe abdomen or extremities trauma.
• Severe bleeding from abdomen or extremities.
• Congenital coagulopathy (Hemophilia, protein S and C deficiency, Factor 5 Leiden deficiency and ...).
• Warfarin, Heparin, Enoxaparin, Dabigatran and other anticoagulation drugs consumption.