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| Name | Class |
|---|---|
| University of Sheffield | OTHER |
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This project is split into 4 sections:
Fetal MRI is rapidly expanding but the choice of sequences (the combination of variables that produce the image and determine whether a specific tissue is highlighted at the expense of other tissues e.g. some sequences highlight areas with a high water content, others highlight tissues with a high fat content) is limited. Additional sequences have the potential to improve the diagnostic accuracy but need to be developed and assessed before replacing the current choices. In addition it is not possible to continue to add sequences to the list used in clinical practice as each one takes time, which is limited in clinical practice. They may also allow other body areas to be imaged successfully e.g. bones and heart that are not currently imaged to a diagnostic level to be useful in clinical practice.
Until recently fetal MRI was restricted in the United Kingdom (UK) to magnet strengths of 1.5T although 3T was safely used in the rest of Europe. The restrictions have been lifted and 3T can now be used in the clinical setting for fetal MRI. The clinical value of this has not been established (1) In this pilot study the investigators will aim to answer the above 4 questions.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients attending for a clinical scan | Other | Patients attending for a clinical scan will be offered 2-4 extra sequences. The additional sequences and compare them to the currently established ones. |
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| Patients who have requested a TOP | Other | Women who have requested a termination of pregnancy (TOP) will be asked if they are willing to have a fetal MRI at 3T performed prior to the TOP. The images obtained will be compared to either images done clinically at 1.5T before the TOP request (if done and with the patients consent) or to images obtained at 1.5T of a similar gestation and pathology that the investigators obtained in a previous research study. |
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| Patients with fetal heart abnormality | Other | The investigators plan to recruit patients with a fetus with heart abnormality on ultrasound and compare the MRI findings with the ultrasound findings and the clinical outcome. |
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| Patient fetal bone abnormalities | Other | The investigators would like to ask women who have a fetus with bone abnormalities if they would be willing to have a fetal MRI. The findings will be compared to the ultrasound findings and the clinical or pathological findings after delivery. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| MRI scan | Diagnostic Test | Addition of advanced imaging sequences for fetal MRI |
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| Measure | Description | Time Frame |
|---|---|---|
| Establish the value of advanced imaging sequences for fetal MRI in clinical practice | Part 1: improved imaging sequences that show areas better than the original sequences. Part 2: improved image quality when compared to similar (historical)cases done at 1.5T. Part 3 and 4: imaging of the fetal heart and bone that will be useful clinically (currently the images are not good enough to provide information for diagnosis and management) Overall improved image detail and quality to aid diagnosis and management. | 3 years |
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Inclusion Criteria:
Exclusion Criteria:
Pregnant females
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Elspeth Whitby | Contact | 01142262081 | e.whitby@sheffield.ac.uk | |
| Loretta Chantry-Groves | Contact | 01142268515 | loretta.chantry-groves@sth.nhs.uk |
| Name | Affiliation | Role |
|---|---|---|
| Elspeth Whitby | University of Sheffield and Sheffield Teaching Hospitals NHS Foundation Trust | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sheffield Teaching Hospital NHS Foundation Trust | Recruiting | Sheffield | South Yorkshire | S10 2SF | United Kingdom |
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| ID | Term |
|---|---|
| D008279 | Magnetic Resonance Imaging |
| ID | Term |
|---|---|
| D014054 | Tomography |
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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Participants will be assigned to appropriate arm depending on outcome of routine obstetric screening
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