CRF - Nociceptin Receptor Interactions

In Vivo Imaging of Corticotropin-releasing Factor - Nociceptin Receptor Interactions

To determine if [C-11]NOP-1A receptor binding (VT) can be altered by an intravenous hydrocortisone (cortisol) challenge through CRF-NOP interactions

Examines changes in [C-11]NOP-1A pharmacokinetics caused by an intravenous hydrocortisone challenge (1 mg/kg)

Inclusion Criteria:

• Males or females between 18 and 40 years old

Exclusion Criteria:

• Current DSM-5 psychiatric disorders
• Binge drinking as defined in NIAAA criteria in the past month
• Recreational abuse of opiates, sedative-hypnotics, cocaine, amphetamines, MDMA, and PCP, as well as cannabis use
• Currently on any prescription medical or psychotropic medication;
• Current or past severe medical, endocrine, cardiovascular, immunological or neurological illnesses
• Currently pregnant or breast-feeding;
• History of radioactivity exposure via prior nuclear medicine studies or occupational exposure in past twelve months
• Metallic objects in the body that are contraindicated for MRI;
• First-degree relative with psychosis or mood disorders