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The overall goal of this study is to study circulating tumor DNA (ctDNA) in the blood to determine how cancer cells in patients react to treatment. DNA is short for deoxyribonucleic acid. DNA contains information that determines in part the traits, such as eye color, height, or disease risk, that are passed on from parent to child. This reaction will be measured by studying patient blood that will be collected before and during treatment until there is disease progression.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Stage IV solid tumors | adult patients with stage IV cancer that are starting a new line of treatment |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| research blood draws | Procedure | Twenty-five mL of peripheral blood (PB) will be collected for research. Blood will be collected in EDTA tubes and used to isolate ctDNA. For each subject we will request that he/she contribute 25 mL of plasma no more frequently than every 6 weeks, and at same time of standard of care blood draws and routine clinic visit, and for no more than 3 times (including baseline and end of study). |
| Measure | Description | Time Frame |
|---|---|---|
| Detecting specific cancer mutations in ctDNA isolated from plasma of stage IV cancer patients at HCC. | 24 months | |
| Changes in patients' ctDNA longitudinal samples through treatment, and when available, of primary tumor and metastasis. | 24 months |
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Inclusion Criteria:
Exclusion Criteria:
- Age < 18-year-old
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Adult patients with stage IV cancer that start a new line of treatment and agree to have blood drawn
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| Name | Affiliation | Role |
|---|---|---|
| Antonio Giordano, MD | Medical University of South Carolina | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Medical University of South Carolina | Charleston | South Carolina | 29425 | United States |
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circulating tumor DNA (ctDNA) in the blood
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