Caffeine for Preterm Infants With Apnea of Prematurity(AOP)

Caffeine for Preterm Infants With Apnea of Prematurity(AOP): a Randomized Controlled Trial

Nowadays,caffein is commonly used for AOP, and it reduces the intubation rate in preterm infants. However, intubation is needed in about 20%-50% of partial neonates. How to reduce the intubation rate effectively is a challenge for neonatologists.

Less evidences about more dose of caffein used in preterm infants.

Inclusion Criteria:

• gestational age less than 32 weeks;
• appear AOP;
• parents'consents are obtained.

Exclusion Criteria:

• major congenital abnormalities;
• Parents' rejection