Sedative-Anxiolytic Effects on Simulated Driving Performance

Alprazolam and Simulated Driving Performance: Next Day Effects

This study evaluates the effect of anxiety drugs taken at night on the ability to drive a car the next day. Participants will receive alprazolam, placebo, or zolpidem at night before bed or in the morning before using a driving simulator to assess impairment.

Inclusion Criteria:

• valid driver's license
• english-speaking and literate

Exclusion Criteria:

• using daily medication for chronic condition
• acute narrow angle glaucoma
• previous adverse experience with study drugs
• experiences motion sickness in response to driving simulator
• BMI > 30
• women who are pregnant, lactating, or planning on becoming pregnant
• regular use of tobacco products
• current substance use disorder
• clinically significant ECG
• current ongoing psychiatric disorder