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| ID | Type | Description | Link |
|---|---|---|---|
| 2016-A00783-48 | Other Identifier | ANSM |
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| Name | Class |
|---|---|
| National Agency for Research on AIDS and Viral Hepatitis (ANRS) | OTHER |
| Institut National de la Santé Et de la Recherche Médicale, France | OTHER_GOV |
| French Ministry of Health through the COREVIH Aquitaine |
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HIV infection is now a chronic disease in countries where antiretroviral treatments (ART) are largely available. Long-term follow-up is required to describe and understand the evolution of morbidities and complications as well as new treatments side effects.
The main objective of the cohort is to describe and study the evolution of HIV infection in ART-treated individuals.
The survival of people living with HIV (PLHIV) taking antiretroviral therapy (ART) is now close to what is reported in the general population in northern countries. However, PLHIV experience an increased risk of morbidities that the ANRS CO3 Aquitaine Cohort has largely contributed to describe in the last years. Among contributing factors to this excess of morbidity, immune suppression, immune activation, and exposition to cardiovascular and cancer risk factors as well as ageing represent possible intervention targets. Long-term follow-up is required to describe and understand the evolution of morbidities and complications as well as ART side effects.
Moreover, the global evaluation of health in PLHIV, including psychiatric, neurologic and social determinants and not only biomedical determinants represents one of the public health challenges of the next decade in the field of HIV infection.
The aim of the present study is to study the emerging morbidity occurring during the course of HIV infection in people treated with ART as well as to describe the tolerance and efficacy of new available ART regimens.
The follow-up of patients will be performed according to national guidelines. Demographic, clinical, biological and therapeutic data will be captured at each patient's hospital contact according to a standardized questionnaire.
All events occurring during the course of clinical management will be prospectively registered in the database according to the ICD 10th revision. A biobank will be collected from every consenting PLHIV at inclusion in the cohort and then every two years.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| HIV patients | 7500 patients infected with HIV-1 |
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| Measure | Description | Time Frame |
|---|---|---|
| Socio-demographic characteristics of people living with the HIV | Each 12 months from baseline for 4 years (M48) |
| Measure | Description | Time Frame |
|---|---|---|
| HIV infection characteristics of people living with the HIV | group of infection, stage of infection, duration since first serology positive, CD4 nadir, last CD4 measurement, CD4 / CD8 ratio | Each 12 months from baseline for 4 years (M48) |
| comorbidities of people living with the HIV |
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Inclusion Criteria:
Exclusion Criteria:
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Patients infected with HIV-1 (PLHIV)
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| Name | Affiliation | Role |
|---|---|---|
| Linda WITTKOP, MD, PhD | ISPED - CHU de Bordeaux | Study Chair |
| Fabrice BONNET, Prof | University Hospital, Bordeaux | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| service de médecine interne - CH d'Agen | Agen | 47923 | France | |||
| Médecine interne - CH d'Angoulême |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36624391 | Derived | Devos S, Bonnet F, Hessamfar M, Neau D, Vareil MO, Leleux O, Cazanave C, Rouanes N, Duffau P, Lazaro E, Dabis F, Wittkop L, Barger D; ANRS CO3-AQUIVIH-NA-QuAliV. Tobacco, alcohol, cannabis, and illicit drug use and their association with CD4/CD8 cell count ratio in people with controlled HIV: a cross-sectional study (ANRS CO3 AQUIVIH-NA-QuAliV). BMC Infect Dis. 2023 Jan 9;23(1):16. doi: 10.1186/s12879-022-07963-6. | |
| 32650781 |
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Blood sampling
| Each 12 months from baseline for 4 years (M48) |
| co-infections of people living with the HIV | Hepatitis B, Hepatitis C, cytomegalovirus infection... | Each 12 months from baseline for 4 years (M48) |
| Therapeutics description | naïve / treated status, dosage | Each 12 months from baseline for 4 years (M48) |
| virological responses | Each 12 months from baseline for 4 years (M48) |
| Angoulême |
| France |
| service de maladies infectieuses - CH de la Côte Basque | Bayonne | 64109 | France |
| service de médecine inter et maladies infectieuses - Hopital Saint André | Bordeaux | 33075 | France |
| service de médecine interne et maladies infectieuses - Hôpital Saint-André | Bordeaux | 33075 | France |
| service de maladies infectieuses et médecine tropicale - Hôpital Pellegrin | Bordeaux | 33076 | France |
| Service D'Urgences Pédiatriques | Bordeaux | France |
| service de médecine interne et maladies infectieuses - CH de Dax | Dax | 40107 | France |
| Médecine Interne - CH de Jonzac | Jonzac | France |
| service de médecine interne - CH d'Arcachon | La Teste-de-Buch | 33260 | France |
| service de médecine interne - CH de Libourne | Libourne | 33505 | France |
| service de médecine interne - CH d'Orthez | Orthez | France |
| service de médecine interne et maladies infectieuses - CH de Pau | Pau | 64000 | France |
| service de médecine interne et maladies infectieuses - Groupe hospitalier Sud | Pessac | France |
| service de médecine interne et maladies infectieuses - CH de Périgueux | Périgueux | 24019 | France |
| Médecine interne et Maladies Infectieuses - CHU de Poitiers | Poitiers | France |
| Médecine interne - CH de Royan | Royan | France |
| Médecine Interne - CH de Saint-Jean-D'Angely | Saint-Jean-d'Angély | France |
| Médecine Interne - CH de Saintonge | Saintes | France |
| Derived |
| Barger D, Hessamfar M, Neau D, Vareil MO, Lazaro E, Duffau P, Rouanes N, Leleux O, Le Marec F, Erramouspe M, Wittkop L, Dabis F, Bonnet F. Assessing the psychometric properties of the French WHOQOL-HIV BREF within the ANRS CO3 Aquitaine Cohort's QuAliV ancillary study. Health Qual Life Outcomes. 2020 Jul 10;18(1):220. doi: 10.1186/s12955-020-01451-8. |
| 31850847 | Derived | Barger D, Leleux O, Conte V, Sapparrart V, Gapillout M, Crespel I, Erramouspe M, Delveaux S, Wittkop L, Dabis F, Bonnet F. Web-Based Module for the Collection of Electronic Patient-Reported Outcomes in People Living With HIV in Nouvelle Aquitaine, France: Usability Evaluation. JMIR Form Res. 2019 Dec 18;3(4):e15013. doi: 10.2196/15013. |
| 29880467 | Derived | Barger D, Leleux O, Conte V, Sapparrart V, Gapillout M, Crespel I, Erramouspe M, Delveaux S, Dabis F, Bonnet F. Integrating Electronic Patient-Reported Outcome Measures into Routine HIV Care and the ANRS CO3 Aquitaine Cohort's Data Capture and Visualization System (QuAliV): Protocol for a Formative Research Study. JMIR Res Protoc. 2018 Jun 7;7(6):e147. doi: 10.2196/resprot.9439. |
| ID | Term |
|---|---|
| D015658 | HIV Infections |
| ID | Term |
|---|---|
| D000086982 | Blood-Borne Infections |
| D003141 | Communicable Diseases |
| D007239 | Infections |
| D015229 | Sexually Transmitted Diseases, Viral |
| D012749 | Sexually Transmitted Diseases |
| D016180 | Lentivirus Infections |
| D012192 | Retroviridae Infections |
| D012327 | RNA Virus Infections |
| D014777 | Virus Diseases |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D007153 | Immunologic Deficiency Syndromes |
| D007154 | Immune System Diseases |
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