The purpose of this project is to study Huntington's disease by metabolomic approach.

Inclusion Criteria:

For all groups:

• age between 20 and 70 years
• signature of the informed consent
• covered by social security

For presymptomatic group:

• positive genetic test with CAG repeat length ≥ 37 in HTT gene
• Unified Huntington Disease Rating Scale ≤ 5

For symptomatic group:

• positive genetic test with CAG repeat length ≥ 37 in HTT gene
• The Unified Huntington's Disease Rating Scale motor score ≥ 6
• The Total Functional Capacity score ≥ 11

Exclusion Criteria for all groups:

• participation in another therapeutic trial (3 months exclusion period)
• pregnancy and breastfeeding
• persons deprived of their liberty by judicial or administrative decision