As the proportion of oral anticancer treatments is continuously increasing, adherence appears as a major issue for patients' outcomes. Poor adherence affects particularly geriatric patients due among others to polypharmacy or cognitive impairment. Thus, the need for educational programs in this population has been regularly emphasized.

PRESTAGE educational program was built after an external and internal analysis of educational needs in elderly patients treated with oral cancer treatments. It implicates a multidisciplinary educational team (nurses, physicians, pharmacists, psychologists, physiologists, social workers...). Six educational workshops were designed with the following endpoints: disease and treatment understanding, treatment management, nutrition and psychological as well as physical well being.

ADOPT-PRESTAGE is a clinical, prospective, interventional, open-label, multicenter, randomized, controlled trial designed to evaluate the impact of PRESTAGE program. It is, to the investigators' knowledge, the first randomized controlled trial evaluating the acceptability and impact (adherence, clinical benefit) of an educational program in an elderly cancer population. The primary endpoint of this trial will be to evaluate adherence using an indirect objective adherence measure: the Medication Event Monitoring System (MEMS). Secondary endpoints include quality of life and evaluation of changes in patients' behaviors.

Inclusion Criteria:

• Patients older than 70 years,
• For which oral anticancer therapy has been initiated within the previous 45 days or will be started within 45 days
• For any type of cancer, solid or hematologic, any stage
• Estimated life expectancy> 6 months
• Affiliation to social security or equivalent
• Patients who can answer questionnaires and protocol evaluations
• Informed consent signed by patients
• Domiciled within 50 km around the investigating center

Exclusion Criteria:

• For patients with breast cancer, exclusive treatment with hormone therapy
• First-generation Hormone Therapy in Prostate Cancer
• Patient not available for regular follow-up whatever the cause (geographic, family, social, psychological)
• Any serious condition, ie serious physical or mental, leading to a disability permanent and likely to prevent the proper course of treatment
• Patient deprived of liberty or under guardianship