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The aim of this study is to compare the value of multifrequency tympanometry between patients with surgical indication of treatment for a Chiari type I malformation and healthy volunteers.
Prevalence of Chiari type I malformation in population is between 0.1% and 0.5%. Chiari type I malformation is responsive in perturbation of the cerebro spinal fluid flow at the cranio-cervical junction. Those perturbations caused headaches, and various otological symptoms (dizziness, tinnitus, vertigo, nystagmus, hypoacousis…). The surgical treatment consists in an occipital craniotomy to restore the cerebro spinal fluid flow at the cranio-cervical junction. Symptoms are due to increasing of the pressure in the cerebellar fossa. 81% of the patients with Chiari type 1 malformation suffer of sub clinical otological perturbations especially alteration of the vestibular test.
In the literature, hearing performance could be normalized after posterior fossa decompression. Furthermore, the multifrequency tympanometry measurement and particularly the width of conductance tympanograms at 2 kHz shows that variations of the cerebro spinal fluid pressure have consequences on the pressure of the perilymph.
Investigator's hypothesis is that tympanometry (conductance) could be an effective test to show the variation of the cerebro spinal fluid pressure.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with Chiari type 1 malformation | Experimental | Tympanometry measurement at inclusion and 6 months after surgery |
|
| Healthy volunteers | Experimental | Tympanometry measurement at inclusion. Every healthy volunteer will be match with a patient for his age and his BMI (body mass index). |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Multifrequency tympanometry at Inclusion | Diagnostic Test | Multifrequency tympanometry measurement and particularly width of conductance tympanograms at 2 kHz will be performed for both group at inclusion |
| Measure | Description | Time Frame |
|---|---|---|
| Width of conductance tympanograms at 2 kHz measurement | Inclusion |
| Measure | Description | Time Frame |
|---|---|---|
| Multifrequency tympanometry | Inclusion and 6 months after surgery for patients with an indication of surgical management for a Chiari type I malformation | |
| Resonance frequency | Inclusion and 6 months after surgery for patients with an indication of surgical management for a Chiari type I malformation |
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Inclusion criteria:
Inclusion criteria for healthy volunteers:
Exclusion criteria:
Exclusion criteria for healthy volunteers:
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| Name | Affiliation | Role |
|---|---|---|
| Antoine BENARD, MD | USMR - CHU de Bordeaux | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU de Bordeaux | Bordeaux | 33076 | France |
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| Multifrequency tympanometry 6 month after surgery | Diagnostic Test | Multifrequency tympanometry measurement and particularly width of conductance tympanograms at 2 kHz will be performed 6 months after surgery for Chiari type I malformation patient |
|
| Audiometric parameters | Inclusion and 6 months after surgery for patients with an indication of surgical management for a Chiari type I malformation |
| Otological symptoms | Inclusion and 6 months after surgery for patients with an indication of surgical management for a Chiari type I malformation |
| Pain measurement with Headache Impact Test | Inclusion and 6 months after surgery for patients with an indication of surgical management for a Chiari type I malformation |
| Cerebro spinal fluid pressure of the cranio cervical junction | Inclusion and 6 months after surgery for patients with an indication of surgical management for a Chiari type I malformation |
| ID | Term |
|---|---|
| D001139 | Arnold-Chiari Malformation |
| ID | Term |
|---|---|
| D009436 | Neural Tube Defects |
| D009421 | Nervous System Malformations |
| D009422 | Nervous System Diseases |
| D000013 | Congenital Abnormalities |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
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