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Population in study will be selected from students and staff of the University of Pisa. Right carotid artery contour wave analysis will be performed during the application of different PEEP levels (from 0 cmH2O to 10 cmH2O) with applanation tonometry technique.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| progressive increasing of PEEP level | Experimental | four-step measurements of central artery blood pressure evaluating contour wave analysis during a progressive increasing of PEEP level. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| progressive increasing of PEEP level. | Other | four-step measurements of central artery blood pressure evaluating contour wave analysis during a progressive increasing of PEEP level First step (Baseline) Subjects spontaneously breathe in air at atmospheric pressure during applanation tonometry. Second step (PEEP=5 cm H2O) Applanation tonometry was performed during the application of PEEP = 5 cmH2O (Oxygen flow = 8lt.- Air flow = 10 lt.). Third step (PEEP= 10 cm H2O) Applanation tonometry was performed during the application of PEEP = 10 cmH2O (Oxygen flow = 15lt.- Air flow = 20 lt.). Fourth step (Recovery) Subjects spontaneously rebreathe air at atmospheric pressure during applanation tonometry. |
| Measure | Description | Time Frame |
|---|---|---|
| hemodynamic variations in wave reflection induced by the application of increasing levels of PEEP in healthy subjects. | Mean blood pressure | at rest and after 5 minutes |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Pisa | Pisa | 56100 | Italy |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35228629 | Derived | Belfiore J, Brogi E, Nicolini N, Deffenu D, Forfori F, Palombo C. Hemodynamic variations in arterial wave reflection associated with the application of increasing levels of PEEP in healthy subjects. Sci Rep. 2022 Feb 28;12(1):3335. doi: 10.1038/s41598-022-07410-1. |
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