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Treatment of patients with end-stage renal disease and critical limb ischemia still poses challenges to vascular medicine due to limited survival, comorbidities and infrapopliteal involvement of arteriosclerosis in these patients.
Most optimal vascular therapy mode has not been finally decided in these patients.
Therefore retrospective analysis of patients receiving open surgical and endovascular revascularisation was performed.
Query of internal clinical database for identification of patients (2009-2017)with end-stage renal disease and critical limb ischemia, receiving either open surgical (Group I "OR") or endovascular revascularisation (Group II "EVT").
Furthermore, retrospective comparison as to morphological criteria (lesion length, peripheral run-off, plantar arch) and comorbidities.
Prospective follow-up of identified patients by means of telephone contacts and/or clinical examination of evaluation of Long-term outcome measures (Overall survival, Amputation-free survival, wound healing)
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| OR | patients treated with open revascularization |
| |
| EVT | patients treated with endovascular revascularization |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| open revascularization | Procedure | surgical revascularization (i.e. Bypass surgery) |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Amputation free survival | Evaluation of limb salvage and survival as Composite endpoint | 24 months |
| Measure | Description | Time Frame |
|---|---|---|
| Overall survival | Evaluation of Overall survival rate | 24 months |
| Major Amputation | Evaluation of Major Amputation rate | 24 months |
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Inclusion Criteria:
Exclusion Criteria:
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study Population comprises of all dialysis patients treated for critical limb ischemia by means of surgical or endiovascular Intervention at University Hospital Erlangen between 2009 and 2017
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| Name | Affiliation | Role |
|---|---|---|
| Alexander Meyer, MD | University Hospital Erlangen, Department of Vascular Sugery | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital | Erlangen | Bavaria | 91054 | Germany |
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| ID | Term |
|---|---|
| D007676 | Kidney Failure, Chronic |
| D000089802 | Chronic Limb-Threatening Ischemia |
| ID | Term |
|---|---|
| D051436 | Renal Insufficiency, Chronic |
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
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| endovascular revascularization |
| Procedure |
endovascular revascularization (stent, ballon angioplasty) |
|
| D052776 |
| Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D058729 | Peripheral Arterial Disease |
| D050197 | Atherosclerosis |
| D001161 | Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D016491 | Peripheral Vascular Diseases |
| D007511 | Ischemia |