The aim of our study is to assess the effect of vaginal progestrone on fetal and maternal doppler indices

A complete Doppler flow assessment of the maternal and fetal circulation was conducted by an independent investigator blinded to the treatment, before and 48 hours after the first administration of 400mg of vaginal progesterone, Voluson E8 (GE Healthcare, Zipf, Austria) ultrasound machine,equipped with a 3.5- MHz curvilinear abdominal transducer with color imaging capabilities, was used in all cases.

Inclusion Criteria:

• Gestational age: 18-33 weeks
• Willing and able to give informed consent
• History of preterm labor (<34 weeks)
• At risk for preterm labor ( increased amniotic fluid volume)
• Short cervical length (<25mm) as incidental finding
• Presenting with actual cervical changes ( dilatation and\or effacement) in current pregnancy

Exclusion Criteria:

• PPROM
• Contraindication to progesterone use
• Diabetic patients, have glucose intolerance
• Multiple pregnancies