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| ID | Type | Description | Link |
|---|---|---|---|
| UL1TR001427 | U.S. NIH Grant/Contract | View source | |
| OCR18882 | Other Identifier | University of Florida |
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| Name | Class |
|---|---|
| National Center for Advancing Translational Sciences (NCATS) | NIH |
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Prospectively evaluate newly established guidelines and make clinicians aware of inter-racial difference in propofol sensitivity.
The primary motivation in conducting this study is to conduct the implementation science, i.e., formalize and train, and retrain if needed, anesthesia providers in the standard practice of titrating infusion rate to effect and clinically evaluate the effect of race and ethnicity on propofol monotherapy sedation during GI endoscopy. The ultimate goal is to make it less likely that patients from races known to be sensitive to propofol experience inadvertent overdosing.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Training intervention | Train anesthesia providers who deliver propofol sedation for GI endoscopy procedures to follow a uniform propofol monotherapy administration guideline to titrate propofol monotherapy infusion to effect according to a standardized protocol. |
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| Effectiveness of training intervention | Compare the effectiveness of training intervention and standardized titration to effect through aggregate data for metrics of recovery times. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Titrate propofol monotherapy infusion to effect | Procedure | Train anesthesia providers in a standardized protocol for titrating propofol infusion to effect. |
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| Measure | Description | Time Frame |
|---|---|---|
| Change in the recovery times among races and ethnicities | Monitored using aggregate data for metrics of recovery times | Change from baseline up to 24 hours |
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Inclusion Criteria:
Exclusion Criteria:
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Patients undergoing propofol sedation at Gainesville (GNV) and Jacksonville (JAX) GI Endoscopy suites
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| Name | Affiliation | Role |
|---|---|---|
| Jeffrey White, MD | University of Florida | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| UF Health | Gainesville | Florida | 32610 | United States |
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| ID | Term |
|---|---|
| D014474 | Unconsciousness |
| C537417 | Butyrylcholinesterase deficiency |
| D000860 | Hypoxia |
| ID | Term |
|---|---|
| D003244 | Consciousness Disorders |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
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Compare in buccal samples the frequency of cytochrome allele carrier status in patients exhibiting sensitivity to propofol during the procedural time against published frequency data in Single Nucleotide Polymorphism database (dbSNP) by race.
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012818 | Signs and Symptoms, Respiratory |